Scott E. Klewer, MD

Professor, Pediatrics
Professor, Cellular and Molecular Medicine
Professor, Medicine
Member, BIO5 Institute
Associate Director of Program Development for the Steele Memorial Children's Research Center
Department of Pediatrics, Section of Pediatric Cardiology
Additional Contact Info: 
Lab: (520) 626-4834
Fax: (520)626-6571
  • Arizona State University 1987 (B.S.)
  • University of Arizona, 1991 (M.D.)
  • University of Iowa Hospitals & Clinics, Iowa City, Iowa, 1991-1993 (Residency, Pediatrics)
  • University of Iowa Hospitals & Clinics, Iowa City, Iowa, 1993-1996 (Fellowship, Pediatric Cardiology)
Honors and Awards: 
University Medical Center Chief of Staff, 2009-2011
Major Areas of Research Interest: 

Dr. Klewer, a professor in The University of Arizona Department of Pediatrics, is a 1991 graduate of the UA College of Medicine. He completed his pediatric residency and a fellowship in pediatric cardiology at the University of Iowa. He is board certified in pediatric cardiology.

Dr. Klewer’s specialty is providing medical care to children with heart problems, and his particular expertise is in the non-invasive imaging of the heart. In addition to caring for patients and teaching medical students and residents, Dr. Klewer is an active researcher in the Sarver Heart Center and the Steele Children’s Research Center, where he is an associate director. He and his research team currently are investigating bicuspid aortic valve (BAV), the most common congenital heart defect, affecting about 3 percent of the population.

His research topics include:

Molecular and genetic analysis of cardiovascular development with an emphasis on role of the extracellular matrix in heart valve formation and blood vessel morphogenesis.

Molecular pathways directing normal and abnormal heart valve development in order to improve the diagnosis and repair of severe congenital heart defects and to understand the development of the human heart, to understand at what point the heart can begin to develop abnormally. Of particular concern are babies who are born with Down syndrome as nearly half of these babies also are born with significant heart defects.

Selected Publications: 
Klewer SE, Yatskievych T, Pogreba K, Stevens MV, Antin PB, Camenisch TD. Has2 expression in heart forming regions is independent of BMP signaling. Gene Expr Patterns. 2006 (E-publication).
Person AD. Klewer SE. Runyan RB. Cell biology of cardiac cushion development. International Review of Cytology. 243:287-335, 2005.
Person AD. Garriock RJ. Krieg PA. Runyan RB. Klewer SE. Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Developmental Biology. 278(1):35-48, 2005.
Gittenberger-de Groot AC. Bartram U. Oosthoek PW. Bartelings MM. Hogers B. Poelmann RE. Jongewaard IN. Klewer SE. Collagen type VI expression during cardiac development and in human fetuses with trisomy 21. Anatomical Record. Part A, Discoveries in Molecular, Cellular, & Evolutionary Biology. 275(2):1109-16, 2003.
Sponsored Research Through MSRP: 
Sam Pak (MSRP 1997): "Characterization of the temporal expression patterns of a novel gene, D-7, in embryonic mouse development."
Gregory Middleton (MSRP 2005): "Non-invasive assessment of children with palliated single-ventricle heart defects using the radial artery contour."
Charity Jackson (MSRP 2005): "Duration of chest pain in a pediatric population."
Sean Behan, 2015; "A Socioeconomic Analysis of Adults Living with a Congenital Heart Defect: Tetralogy of Fallot in a Diverse Patient Population"
Sylvestor (Sammy) Moses (MSRP 2016) "Fontan Physiology and Fontan Complications in Children with Univentricular Heart Disease."
Advanced Research Distinction Track (RDT): 

Sean Behan, (RDT Class of 2018): "A Socioeconomic Analysis of Adults Living with a Congenital Heart Defect: Tetralogy of Fallot in a Diverse Patient Population"

NIH High School Student Research Program: 
-Lilian Gomez, Tucson Junior Academy, 1997
-Kai Loughlin, Corona del Sol High School, 1999
-Elissa Eller, Xavier College Prep, 2003
Tuesday, March 6, 2018