Professor, Physiology
Associate Professor, Pharmacology
Professor, BIO5 Institute
Director, Aribi Institute
Professor, Biomedical Engineering
Professor, Physiological Sciences - GIDP
Associate Director, Shared Resources
Associate Professor, Pharmacology
Professor, BIO5 Institute
Director, Aribi Institute
Professor, Biomedical Engineering
Professor, Physiological Sciences - GIDP
Associate Director, Shared Resources
Education:
- University of Cincinnati, 1983 (Ph.D.)
Honors and Awards:
- National Research Service Award 1984-1987
- Charles A. King Fellowship for Medical Research 1988-1990
Major Areas of Research Interest:
- Regulation of insulin secretion from the pancreas
- Regulation of smooth muscle contractility and blood flow
Student Opportunities Through Research:
- Utilization of microscopic image acquisition and processing technique to study the pathways for cell excitation in the beta cell of the pancreas (insulin secretion) and the smooth muscle cell (blood flow regulation).
- Computer programming, optical design and development, biochemical preparation of fluorescent probes, state of the art microscopic techniques to study physiology of single living cell, and biochemical characterization of cell metabolism are areas of research which can be pursued during a fellowship.
Selected Publications:
Kang YS, Do Y, Lee HK, Park SH, Cheong C, Lynch RM, Loeffler JM, Steinman RM, Park CG.
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.Cell. 2006 125(1):47-58, 2006.
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.Cell. 2006 125(1):47-58, 2006.
Xu L, Dixit MP, Nullmeyer KD, Xu H, Kiela PR, Lynch RM, Ghishan FK. Regulation of Na(+)/H(+) exchanger-NHE3 by angiotensin-II in OKP cells. Biochim Biophys Acta. 1758(4):519-526, 2006.
Martinez-Zaguilan R, Tompkins LS, Gillies RJ, Lynch RM. Simultaneous analysis of intracellular pH and Ca2+ from cell populations. Methods Mol Biol. 312:269-87, 2006.
Landowski TH, Megli CJ, Nullmeyer KD, Lynch RM, Dorr RT. Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines. Cancer Res. 65(9):3828-36, 2005.
Sutherland VL, McReynolds M, Tompkins LS, Brooks HL, Lynch RM. Developmental expression of glucokinase in rat hypothalamus. Brain Res Dev Brain Res. 154(2):255-8, 2005.
Sponsored Research Through MSRP:
Matthew Wilks, (MSRP 1991): "Hexokinase localization in insulin excitation-secretion coupling."
Casey Charlton, (MSRP 2017): "Imaging and Analysis of Mass and Function of Insulin Replacement Devices"
Emily Harnois, (MSRP 2022): "Kisspeptin Effects on B-cell Insulin Secretion"
NIH K-12 Science Teacher Program:
Nancy Garavito, Buena High School, Sierra Vista, Arizona, 1997
Tuesday, March 6, 2018