Nathan Ellis, PhD

Professor, Cellular and Molecular Medicine
Chair, Genetics
Associate Professor, Cancer Biology
Co-Program Leader, Cancer Biology Research Program

Education:

St. Johns College – Annapolis, MD, 1979 (B.S.
University of Washington (Genetics) – Seattle, WA, 1987 (Ph.D)
Imperial Cancer Research Fund, London, UK 1990 (Post-doctoral Fellowship)

Major Areas of Research Interest:

The Ellis laboratory is dedicated to investigation of the relationship between genomic instability and cancer susceptibility. Genomic instability is a dominant feature of cancer cells, and it is the central phenotype of a large group of clinical entities in which cancer development is the main and often fatal consequence.

Selected Publications:

Yazici C*, Wolf PG*, Kim H, Liu TW, Vermillion K, Carroll T, Augustus GJ, Mutlu E, Tussing-Humphreys L, Braunschweig C, Xicola RM, Jung B, Llor X, Ellis NAπ, Gaskins HRπ. Race-dependent association of sulfidogenic bacteria with colorectal cancer. Gut 2017 (in press); (*equal contribution; πco-corresponding)

Xicola RM, Bontu S, Doyle BJ, Rawson J, Garre P, Lee E, de la Hoya M, Bessa X, Clofent J, Bujanda L, Balaguer F, Castellví-Bel S, Alenda C, R, Ruiz-Ponte C, Syngal S, Andreu M, Carracedo A, Castells A, Newcomb PA, Lindor N, Potter JD, Baron JA, Ellis NA, Caldes T, LLor X. Association of a let-7 miRNA binding region of TGFBR1 with hereditary MMR proficient colorectal cancer (MSS HNPCC). Carcinogenesis 2016. 37:751-758. PMID: 27234654 PMCID: PMC4967215

Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis N, Xicola RM, Adeyinka LO, Carethers JM, Brim H, Nouraie M. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016; 7:34546-34557. PMID: 27120810.

Markowitz SD, Nock NL, Schmit SL, Stadler ZK, Joseph V, Zhang L, Willis JE, Scacheri P, Veigl M, Adams MD, Raskin L, Sullivan JF, Stratton K, Shia J, Ellis N, Rennert HS, Manschreck C, Li L, Offit K, Elston RC, Rennert G, Gruber SB. A germline variant on chromosome 4q31.1 associates with susceptibility to developing colon cancer metastasis. PLoS One. 2016. 11:e0146435. PMID: 26751797; PMCID: PMC4709047.

Grimm WA, Messer JS, Murphy SF, Nero T, Lodolce JP, Weber CR, Logsdon MF, Bartulis S, Sylvester BE, Springer A, Dougherty U, Niewold TB, Kupfer SS, Ellis N, Huo D, Bissonnette M, Boone DL. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2016 65:456-464. PMID: 25645662; PMCID: PMC4789828.

Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. BMC Genomics. 2015; 16:138. PMID: 25766683; PMCID: PMC4351699.

Xicola RM, Gagnon M, Clark JR, Carroll T, Gao W, Fernandez C, Mijic D, Rawson JB, Janoski J, Rajaram P, Gluskin AB, Regan M, Chaudhry V, Abcarian H, Blumetti J, Cintron J, Melson J, Xie H, Guzman G, Emmadi R, Angelova V, Kupfer SS, Braunchweig C, Ellis NAπ, Llor Xπ. Excess microsatellite-stable cancer in the proximal colon in African Americans in a multi-ethnic study. Clin Cancer Res. 2014; 20:4962-4970 (πco-corresponding authors). PMID: 25013126 ; PMCID: PMC4167473.

Kupfer SS, Skol A, Hong E, Ludvik AE, Miller A, Kittles RA, Keku TO, Sandler RS, Ellis NA. Shared and independent colorectal cancer alleles in African and European Americans. Carcinogenesis 2014; 35:2025-2030. PMID: 24753543; PMCID: PMC4146413.

Pibiri F, Kittles RA, Sandler RS, Keku TO, Kupfer SS, Xicola R, Llor X, Ellis NA. Genetic variation in vitamin D-related genes and risk of colorectal cancer in African Americans. Cancer Causes and Control 2014; 25:561-570. [PMID: 24562971; PMCID: PMC3978221.

Ouyang K, Yagle MK, Matunis MJ, Ellis NA. BLM SUMOylation regulates ssDNA accumulation at stalled replication forks. Frontiers in Genetics 2013; 04 September, doi: 10.3389/ fgene.2013.00167. PMID: 24027577; PMCID: PMC3761158]

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