Monika Schmelz, PhD

Associate Professor, Applied BioSciences - GIDP
Associate Professor, Pathology - (Research Scholar Track)
MS: Biology Karl Ruprecht University of Heidelberg, 1982
PhD: Cell & Tumor Biology, German Cancer Research Center,1989
Research Activities: 

 Mechanism of Lymphoma

Selected Publications: 
Kendrick S, Rimsza LM, Scott DW, Slack GW, Farinha P, Tan KL, Persky D, Puvvada S, Connors JM, Sehn L, Gascoyne RD, Schmelz M. Aberrant cytoplasmic expression of MHCII confers worse progression free survival in diffuse large B-cell lymphoma. Virchows Archiv, 2017, Vol 470 (1), 113-117. (DOI: 10.1007/s00428-016-2041-7; PMID: 27888357).
Puvvada SD, Li H, Rimsza LM, Bernstein SH, Fisher RI, LeBlanc M, Schmelz M, Glinsmann-Gibson B, Miller TP, Maddox AM, Friedberg JW, Smith SM, Persky DO.  A phase II study of belinostat (PXD101) in relapsed and refractory aggressive B-cell lymphomas: SWOG S0520. See comment in PubMed Commons belowLeukemia & Lymphoma, 2016 Jan 12:1-11. [Epub ahead of print].
Redd L, Schmelz M, Burack R, Cook JR, Day AW, Rimsza LM. Langerhans Cell Histiocytosis (LCH) shows distinct cytoplasmic expression of the major histocompatibility class II antigen (MHCII) in LCH. J. Hematopathology, 2016, 9: 107-112. DOI 10.1007/s12308-016-0272-9. (
 Havas AB, Rodrigues KB, Bhakta A, Demirjian JA, Hahn S, Tran J, Scavello M, Tula-Sanchez AA, Zeng Y, Schmelz M, Smith CL. Belinostat and vincristine demonstrate mutually synergistic cytotoxicity associated with mitotic arrest and inhibition of polyploidy in a preclinical model of aggressive diffuse large B cell lymphoma. Cancer Biology & Therapy 2016, Vol 0, No. 0, 1-13. (
Schmelz M, Montes-Moreno S, Piris MA, Wilkinson ST, Rimsza LM.  Lack and/or aberrant localization of major histocompatibility Class II (MHCII) protein in plasmablastic lymphoma. Haematologica  97(10):1614-6; 2012.
Jensen, V., A. R. Prasad, A. Smith, M. Raju, C. S. Wendel, M. Schmelz, W. Leyva, J. Warneke, and R. S. Krouse, "Prognostic criteria for squamous cell cancer of the skin.", J Surg Res, vol. 159, issue 1, pp. 509-16, 2010 Mar. PMID: 19375720
Thai, H. M., E. Juneman, J. Lancaster, T. Hagerty, R. Do, L. Castellano, R. Kellar, S. Williams, G. Sethi, M. Schmelz, et al., "Implantation of a three-dimensional fibroblast matrix improves left ventricular function and blood flow after acute myocardial infarction.", Cell Transplant, vol. 18, issue 3, pp. 283-95, 2009. PMCID: PMC2739416  PMID: 19558777
Li, L., M. Schmelz, E. M. Kellner, J. N. Galgiani, and M. J. Orbach, "Nuclear labeling of Coccidioides posadasii with green fluorescent protein.", Ann N Y Acad Sci, vol. 1111, pp. 198-207, 2007 Sep. PMID: 17344520
Kremer, C. L., M. Schmelz, and A. E. Cress, "Integrin-dependent amplification of the G2 arrest induced by ionizing radiation.", Prostate, vol. 66, issue 1, pp. 88-96, 2006 Jan 1. PMCID: PMC2732347  PMID: 16114062
Li, L., S. M. Dial, M. Schmelz, M. A. Rennels, and N. M. Ampel, "Cellular immune suppressor activity resides in lymphocyte cell clusters adjacent to granulomata in human coccidioidomycosis.", Infect Immun, vol. 73, issue 7, pp. 3923-8, 2005 Jul. PMCID: PMC1168614  PMID: 15972478
Sponsored Research Through MSRP: 

Julia Freeman (MSRP 2017): "MHC II Trafficking in Lymphoma (DLBCL) and its Impact on MHC II Expression"

NIH High School Student Research Program: 
Frances Esparza, 2001, Cholla High School
Jaylene Arvizu, 2015, Nogales High School
Agustin Contreras, 2016, San Luis High School
Thursday, February 23, 2017