Michael D. L. Johnson, PhD

Associate Professor, Immunobiology
Associate Dean, Basic Science Research and Graduate Studies
Associate Professor, BIO5 Institute
Associate Professor, Applied BioSciences - GIDP 
Endowed Professor, Keating Family for Interdisciplinary Research at BIO5 Institute
 
Education: 
  • Duke University, 2004 ( A.B. Music; Minor in Chemistry)
  • University of North Carolina at Chapel Hill, 2011, (Ph.D. Biochemistry and Biophysics)
Honors and Awards: 
Major Areas of Research Interest: 
Metals serve as vital nutrients to all biological systems. The overall goal of my laboratory is to investigate how bacteria maintain homeostasis within the metal milieu. This goal involves determining how metals are processed, the orchestrated response during metal sensing, and the role that the host plays in this process during infection. Understanding how bacteria interact with metals during infections will identify novel therapeutic strategies against bacterial infections. 
 
Selected Publications: 
O'Brien, H., T. Davoodian, and M. D. L. Johnson, "The promise of copper ionophores as antimicrobials.", Curr Opin Microbiol, vol. 75, pp. 102355, 2023 Oct. PMCID: PMC10529258  PMID: 37406562
 
Menghani, S. V., M. P. Cutcliffe, Y. Sanchez-Rosario, C. Pok, A. Watson, M. J. Neubert, K. Ochoa, H-J. Joyce Wu, and M. D. L. Johnson, ",-Dimethyldithiocarbamate Elicits Pneumococcal Hypersensitivity to Copper and Macrophage-Mediated Clearance.", Infect Immun, pp. e0059721, 2022 Mar 21. PMID: 35311543
 
Menghani, S. V., M. P. Cutcliffe, Y. Sanchez-Rosario, C. Pok, A. Watson, M. J. Neubert, K. Ochoa, H-J. Joyce Wu, and M. D. L. Johnson, ",-Dimethyldithiocarbamate Elicits Pneumococcal Hypersensitivity to Copper and Macrophage-Mediated Clearance.", Infect Immun, pp. e0059721, 2022 Mar 21. PMID: 35311543
 
O'Brien, H., J. W. Alvin, S. V. Menghani, K. Van Doorslaer, and M. D. L. Johnson, "Rules of expansion: an updated consensus operator site for the CopR/Y family of bacterial copper exporter system repressors", mSphere.00411-20 , vol. 1128, 05/2020.
 
Sponsored Research Through MSRP: 

Arielle De La Cruz (MSRP 2024): "The Effect of Bacterial Carbohydrate Consumption on Sepsis Biomarkers"

Wednesday, August 28, 2024