Marvin J. Slepian, MD

Professor, Medicine
Clinical Professor, Biomedical Engineering
Associate Department Head, Clinical / Industrial Affairs
Professor, Biomedical Engineering - GIDP
Professor, Materials Science and Engineering
MD: University of Cincinnati College of Medicine, 1981
Honors and Awards: 
Chairman, Science Advisory Board for MicroMed Cardiovascular, 2009
Major Areas of Research Interest: 

Innovation Science and Invention;Inventive Knowledge Flow;Intravascular Stents;Intravascular Biodegradable Polymer-based Support and Drug Delivery Systems - Polymeric Endoluminal Paving and Sealing;Cell Biology of Restenosis and Vascular Wound Healing;Intravascular Ultrasound Imaging;Smooth muscle cell integrin - matrix interactions; Integrin Biology – role in cell locomotion;Estrogen and Smooth Muscle Cell Migration and Integrin Expression;Myocardial angiogenesis and alternative revascularization means;Mechanical Circulatory Support – TAH/VAD, Mechanical & Biomaterial Issues;Oral-Body Inflammatory Connection – Periodontal Disease and CAD;Flexible/Stretchable Bioelectronics;Microfluidics and Medical Diagnostics;Microchip Medical Diagnostics;Grape Polyphenolics, Inflammation and CAD;Bioglass Biomaterials;Nanotextured Biomaterials/Surface Endothelialization;Mathematical Modeling/Enhanced CFD of Mechanical Circulatory Support; Systems for Improved Thromboresistance;Biodegradable/Transient electronic systems;Wearable Health Systems;Microfluidic Point-of-Care Systems;Big Data Tools for Health Care;Microbiome and Its Impact on CV Diz and Chronic Disease;Piezoelectric Biomaterials;Soft Robotics;Virtual Realty Systems;

Selected Publications: 

Consolo, F., Dimasi, A., Rasponi, M., Valerio, L., Pappalardo, F., Bluestein, D., Slepian, M. J., Fiore, G. B., & Redaelli, A. (2016). Microfluidic approaches for the assessment of blood cell trauma: a focus on thrombotic risk in mechanical circulatory support devices. The International journal of artificial organs, 0.

Copeland, J., Copeland, H., Nolan, P., Gustafson, M., Slepian, M., & Smith, R. (2016). Results with an anticoagulation protocol in 99 SynCardia total artificial heart recipients. ASAIO journal (American Society for Artificial Internal Organs : 1992), 59(3), 216-20.

Crosby, J. R., DeCook, K. J., Tran, P. L., Smith, R. G., Larson, D. F., Khalpey, Z. I., Burkhoff, D., & Slepian, M. J. (2016). Physiological characterization of the SynCardia total artificial heart in a mock circulation system. ASAIO journal (American Society for Artificial Internal Organs : 1992), 61(3), 274-81.

El Banayosy, A., Kizner, L., Arusoglu, L., Morshuis, M., Brehm, C., Koerfer, R., Schuermann, C., Smith, R. G., Copeland, J. G., & Slepian, M. J. (2016). Home discharge and out-of-hospital follow-up of total artificial heart patients supported by a portable driver system. ASAIO journal (American Society for Artificial Internal Organs : 1992), 60(2), 148-53.

Herskowitz, A., Tamura, F., Ueda, K., Neumann, D. A., Slepian, M., Rose, N. R., Beschorner, W. E., Baumgartner, W. A., Reitz, B. R., & Sell, K. W. (2016). Induction of donor major histocompatibility complex antigens in coronary arterial vessels: mechanism of arterial vasculitis in rat allografts treated with cyclosporine. The Journal of heart transplantation, 8(1), 11-9.

Khalpey, Z., Bin Riaz, I., Marsh, K. M., Ansari, M. Z., Bilal, J., Cooper, A., Paidy, S., Schmitto, J. D., Smith, R., Friedman, M., Slepian, M. J., & Poston, R. (2016). Robotic Left Ventricular Assist Device Implantation Using Left Thoracotomy Approach in Patients with Previous Sternotomies. ASAIO journal (American Society for Artificial Internal Organs : 1992), 61(6), e44-6.

Sponsored Research Through MSRP: 
Theodore Lin, (MSRP 2016): "Porogenicity of Platelets"
Catherine Jerman, (MSRP 2017): "Acoustic-Activation of Platelets: A Newly Recognized Mechanism Underlying Thromboembolic Events Associated with Snoring and Obstructive Sleep Apnea -- An Examination of Mechanisms and Modulation"
NIH Undergraduate Diversity Program: 
Katrina DeCook, 2012, "Effect of ECM Proteins on HUVEC Migration"
Corey Edwards, 2013, "Biomedical Engineering: Summer Clinical Immersion 2013"
Samuel Dunn, 2014, "Red Blood Cell Hemolysis: Is it a Risk or a Marker Factor in VAD Thrombosis?"
Emily Ramirez, 2014, 2015: "The Effects of BMP-13 on the Osteogenic Activity of hASCs", "Investigating New CPR Methods and Repairing Heart Tissue with Cell-Based Therapy"
NIH High School Student Research Program: 
Gaddy Lopez, Cholla High School, 2016
Paloma Orozco, Rio Rico High School, 2016
Kyle Wilson, Greyhills Academy High School 2017
Wednesday, August 30, 2017