Marlys H. Witte, MD

Professor, Surgery
Director, Medical Student Research Program,
High School Student and K-12 Science Teacher Research Program, Curriculum on Medical Ignorance
Director, Lymphology Laboratories
  • New York University School of Medicine, New York, NY, 1960 (M.D.)
  • North Carolina Memorial Hospital, Chapel Hill, North Carolina, 1960-1961 (Internship)
  • Bellevue Hospital, New York City, New York, 1961-1965 (Residency, Internal Medicine)
Honors and Awards: 
  • Alpha Omega AlphaPast Program Director
  • UA NIH Clinical Research Center in SurgeryEstablished Investigatorship American Heart Association USPHS (NHLBI) Career Research Development Award
  • Past President, International Society of Lymphology
  • Secretary-General, International Society of Lymphology
  • Executive Editor, Journal of LYMPHOLOGY
  • Visiting Litchfield Lecturer, University of Oxford, England, 1988
  • University of Arizona Mortar Board Hall of Fame Award for recognizing leadership, concern for individual students, and promotion of high academic standards, 1989
  • Commencement Speaker, St. Louis University School of Medicine (first woman speaker since the university was founded in 1818), 1989
  • UA College of Medicine Gold Headed Cane Award; Senior Class Distinguished Science Award; Founders Day Award, 1993
  • National Academy of Medicine of Brazil, 1996
  • Excellence in Innovation in Teaching, 2004
Major Areas of Research Interest: 

Principal research has been in the field of lymphology -- care of patients with disorders involving the lymph circulation, liver and spleen, particularly edematous states; experimental and clinical research into the pathophysiology and treatment of these diseases, and undergraduate, post-graduate, and continuing education in lymphology and hepatosplenology.

  • Characterization of normal lymphatic and neoplastic endothelium
  • Role of lymph circulation in edematous states
  • Pathophysiology of lymphatic filariasis
  • Lymphatic imaging
  • Kaposi sarcoma models
  • Medical and other ignorance
Student Opportunities Through Research: 
  • Wide variety of basic and clinical projects - from cell biology to field research in the Third World
  • Learning to pose and pursue questions - from the idea to publication
  • Cutting edge of biotechnology
  • National and international collaborations and where earned, travel to international meetings
  • Excitement of discovery
  • Close contact and interactions with mentors
Sponsored Research Through MSRP: 

John Myers II (MSRP 1981): "Estimated net transcapillary fluid and protein flux in experimental extrahepatic portal hypertension and techniques to measure capillary blood flow."

Kent Wellish (MSRP 1983, 1984): "Circulatory control of splenic function and post-splenectomy sepsis."

Albert Martinez (MSRP 1986): "Lymphatic endothelium and AIDS-related syndromes." and "Influence of peritoneovenous shunting on atrial natriuretic factor in human and experimental cirrhotic ascites."

Steven Shapiro (MSRP 1987): "An in vitro study of lymphogenous vs. hematogenous dissemination of sarcoma, melanoma, and carcinoma cells."

Michael Stuntz (AHA FELLOWSHIP 1987-1988): "The effects of interleukin 2 on vascular permeability and lymph dynamics in the rat." and "The lymphatic system in AIDS-Kaposi's sarcoma."

Jane Hartline (MSRP 1991): "In vitro and in vivo studies of lymphatic filariasis."

Gina Escobar (AHA FELLOWSHIP, 1992-1993): "In vivo and in vitro microscopy of adult Brugia malayi lymphatic filariasis: The effect of macrofilaricidal agents." and "AIDS-Kaposi sarcoma."

Troy Manchester (MSRP 1992): "Growth factor and cytokine modulation in endothelial cell isolates in vitro."

Richard Mularski (MSRP 1992): "Sinusoidal capillarization of hepatic tissue in a rat model under chronic alcohol ingestion."

Anthony Stazzone (MSRP 1994): "Establishing an in vitro assay of lymphocyte/endothelial cell interactions." and "Improved rehabilitation in lymphedemas."

Frank Reiser (MSRP 1995, 1996): "Effects of 2-methoxyestradiol on inhibition of angiogenesis and endothelial tumor growth."and "Searching for the lymphangiogenesis gene(s)."

Teressa Myloyde (MSRP 1997): "Quantitative lymphangioscintigraphy in an experimental lymphedema model."

Jeanne Cheshier-Alvarado (MSRP 1998,1999): "A genotypic and phenotypic correlation in Turner and familiar lymphedema syndromes."

Clifford Martin (MSRP 1998, 1999, 2000): "Vascular endothelial growth factors, vascular permeability and lymphangiogenesis."

Catherynne Morgan Goldman (MSRP 2002): "The effects of estrogen and tamoxifen on lymph formation in the intestine."

Parker Fillmore (MSRP 2003): "Massage therapy in experimental and human lymphedema."

Megan Meislin (MSRP 2004): "Caveolin in Neiman Pick Type C mice."

Gideon Richards (MSRP 2004, 2007): "Non-invasive lymphatic imaging in mouse models" and "Non-invasive lymphatic imaging in mouse models of post-natal lymphangiogenesis."

Chad Cherrington (MSRP 2005, 2007): "Imaging of post-natal lymphangiogenesis."

Aaron Scott (MSRP 2007): "Isolation of neural stem cells from the adult human and mouse hippocampus."

Drew Kurtzman (MSRP 2008): "Assessing the role of lymphatics in metastatic neoplasms."

Michael Montague (MSRP 2009): "Lymphatic dysfunction, melanoma growth and rattlesnake envenomation in pre-clinical animal models."

Matthew Douglas (MSRP 2010): "Role of Lymphatics in Melanoma Metastasis and Envenomation in Murine Models"

Eric Parmon (MSRP 2011): "Evaluation of the Role of Amifostine and its Metabolite WR-1065 in Preventing Radiation Induced Lymphatic Injury"

Sarah Daley (MSRP 2011, 2016): "Progression of Inflammatory Bowel Disease to Cancer: Is the Patient 'Better Off' Without Lymphatic Vessels or Nodes (or Angiopoietin 2)?"

Emily Wilkinson (MSRP 2011): "Molecular Biology of Vertically Transmitted T. Cruzi Infection in Argentina"

Nathan Tanoue, (MSRP 2014), "Intestinal Microbiome Alternations"; 2015; "Evaluation of Pathology and Histology of Inflamed and Cancerous Mouse Colon"; 2016, "Vascular Growth Factors and Cytokines in Progression of Experimental Colitis"

Jeremey Gneck, (MSRP 2016); "Effect of Genetics in Lymph-Vascular Deficiency on Gut Microbiota"

Sylvestor "Sammy" Moses, (MSRP 2016); "Fontan Physiology and Fontan Complications in Children with Univentricular Heart Disease"

Advanced Research Distinction Track (RDT): 

Teressa Myloyde (RDT Class of 2001): "Magnetic resonance imaging (MRI) of the lymphatic system: Experimental studies and clinical background.

Kimberly Northup (RDT Class of 2002): "Syndromic classifications of hereditary lymphedema."

Megan Meislin (RDT Class of 2009): "Vascular genomics of post-natal lymphangiogenesis."

Chad Cherrington (RDT Class of 2010): "The conditions of lymphatic disruption that best prevent tumor metastasis to lymph nodes."

Anne Floyd (RDT Class of 2012): "Study of Functional and Structural Changes Between Wild Type and Mucin Knockout Mice"

Sarah Daley (RDT Class of 2016): "Progression of Inflammatory Bowel Disease to Cancer:  Is the Patient “Better Off” Without Lymphatic Vessels or Nodes (or Angiopoietin 2)?"

Sean Behan (RDT Class of 2018): "A Socioeconomic Analysis of Adults Living with a Congenital Heart Defect: Tetralogy of Fallot in a Diverse Patient Population"

Nathan Tanoue (RDT Class of 2018): "An Animal Model for Fecal Transplant in IBD"

NIH Undergraduate Diversity Program: 

Jalicia C.S. Washington, 2011, "Angiopoietin 2 Lymphatic Insufficiency in Murine Inflammatory Colitis"; 2012, "Colon Cancer/IBD in Mouse Models"; 2013, "Inflammatory Bowel Disease in Mouse Models: Role of Lymphatics"; 2014, "Inflammatory Colitis, Lymphatic Insufficiency and Progression to Colorectal Cancer in an Experimental Mouse Model"

Alvin Rodriguez, 2012, "Progression of Inflammatory Bowel Disease to Cancer"; 2013, "Lymphatic Insufficiency and Inflammatory Colitis"

Jorge P. Gonzalez, 2015; "The issues surrounding the choroid plexus haemorrhage"

NIH High School Student Research Program: 
-Esteban E. Loustaunau, Pueblo High School, 1987
-Raymond Coronado, Pueblo High School, 1987
-Shella Lynette Chamberlain, Sahuaro High School, 1988
-Lillian Gallegos, Desert View High School, 1989
-Lisa M. Gonzales, Flowing Wells High School, 1990
-Val T. Hill, Tucson High School, 1990
-Julieta Pettibone Tinajero, Sahuaro High School, 1991, 1992
-Barbara Leung, Salpointe Catholic High School, 1993
-Lorenzo Scott, Baboquivari High School (Sells, AZ), 1993
-Mario Lamas, Pueblo High School, 1994
-Michelle Jensen, Tuba City High School (Tuba City, AZ), 1994
-Steven Hernandez, Dysart High School (El Mirage, AZ), 1995
-Paloma Beope, Salpointe Catholic High School, 1996
-Koranda Wallace, University High School, 1996
-Nanibaa' Garrison, Kirtland Central High School (Kirtland, NM), 1997
-Lorenzo Ortiz, Salpointe Catholic High School, 1997, 1998
-Ferrin Travis, Tucson High Magnet School, 1999
-Serina D. Preciado, Flowing Wells High School, 2000
-Mohammed Abdelwahab, Tucson High Magnet School, 2001
-Elyce T. Antone, Baboquivari High School (Sells, AZ), 2001
-Sarah D. Rawdin, Amphitheater High School, 2001
-Montgomery Johnson, Baboquivari High School (Sells, AZ), 2002
-Resha Watts, Santa Rita High School, 2002
-Alia M. Carter, Buena High School (Sierra Vista, AZ), 2003
-Phillip Fung, Rincon High School, 2003
-Manuel McKenna, Salpointe Catholic High School, 2003
-Kristine C. Holden, Alchesay High School (White River, AZ), 2004
-Morgan Stimmel, Santa Rita High School, 2005

-Thurman Thomas, Window Rock High School (Window Rock, AZ), 2006
-Karen Peralta, Yuma Union High School (Yuma, AZ), 2007
-Kathleen manuel, Baboquivari High School, 2008
-Sophie Park, Tucson Magnet High School, 2008
-Samantha R. Sawyer, Douglas High School (Douglas, AZ), 2009
-Noah Flake, Snowflake High School, 2010
-Dionne Lopez, Baboquivari High School, 2010
-Araceli Vidal, Cholla High School, 2010
-Martina Sepulveda, San Luis High School, 2011
-Kali Cornn, Catalina Foothills High School, 2012
-Naila Littell, Trevor G Browne High School, 2013, 2014
NIH K-12 Science Teacher Program: 
-Frank Moraga, Nogales High School, 1991
-Virginia Johnson, Nogales High School, 1992
-Brenda Witt, Sabino High School, 1993
-Randolfo Palacio, Roskruge Bilingual Middle School, 1994
-Kari Lane Green Neumann, Kofa High School (Yuma, AZ), 1995
-Sophie Compton, Maxine O. Bush Elementary School, 1996
-Daniel Montoya, University of Arizona, 1997
-Stacey Rich, Flowing Wells High School, 1999
-James W. Phillips, Sahuarita High School, 2000
-Michele B. Fournier, Mission Manor Elementary School, 2002
-Leslee Kientzler, Santa Rita High School, 2004
Friday, January 13, 2017