Kurt Richard Denninghoff, MD

Professor of Emergency Medicine
Professor of Optical Sciences
Medical Director for Research AEMRC
  • Vanderbilt University, 1983 (BS, Biomedical and Electrical Engineering)
  • Vanderbilt University School of Medicine, 1987 (MD)
  • Charity Hospital, New Orleans, 1987-1988 (Internship, General Surgery)
  • Charity Hospital, New Orleans, 1988-1991 (Residency, Emergency Medicine)
Honors and Awards: 
  • Award for “Significant Contributions to Research in Emergency Medicine” the University of Alabama at Birmingham, Department of Emergency Medicine, 2005
  • Winner of the Pascal Rol Award for Excellence in Ophthalmic Technologies at the SPIE 2001 National Meeting, 2001
  • Outstanding Scholars of the 21st Century, International Biographical Center, Cambridge, England, 2001,2000
  • Marquis Who's Who in Science and Engineering, 1999
  • Resident Research Competition, Southern Medical Association, 1991
  • Biomedical Engineering Award "Judged by the program faculty to have made the greatest progress in professional development as an undergraduate", Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, 1983
  • Tau Beta Pi, Engineering Honorary Society, 1983
  • Eta Kappa Nu, Electrical Engineering Honorary Society, 1983
Selected Publications: 
Denninghoff KR: “Enrollment of sudden cardiac death victims into a limited cardiac autopsy study in the emergency department: The effects of race” Journal of the National Medical Association. Vol. 92 (1) 36-38, January, 2000.
Smith MH, Denninghoff KR, Lompado A, Hillman LW: “Effect of multiple light paths on retinal vessel oximetry” Applied Optics. 39(7):1183-1193, March, 2000.
McNutt S, Denninghoff KR, Terndrup T: Shock: “Rapid recognition and appropriate ED intervention” Emergency Medicine Practice. Vol. 2 (8) 1-24, August, 2000.
Denninghoff KR, Smith MH: “Optical model of the blood in the large retinal vessels” Journal of Biomedical Optics, Vol. 5 (4) 1-4, October, 2000.
Denninghoff, KR, Smith, MH, Lompado, A, Hillman, LW: “Retinal venous oxygen saturation and cardiac output during controlled hemorrhage and resuscitation” J Appl Physiol 94, 891-896, March, 2003
Salyer, DA, Beaudry, N, Basavanthappa, S, Twietmeyer, K, Eskandari, M, Denninghoff, KR, Chipman, RA, Park, RI. “Retinal oximetry using intravitrial illumination” Curr Eye Res 31(7-8):617-27, 2006
Denninghoff, KR, Chipman, RA, Hillman, LW: “Oxyhemoglobin Saturation Measurements by Green Spectral Shift” Opt Lett 31(7), 924-926, April, 2006
Denninghoff, KR, Chipman, RA, Hillman, LW: Blood Oxyhemoglobin Saturation Measurements by Blue Green Spectral Shift, Accepted for publication by The Journal of Biomedical Optics 2/2007
1. US 6,390,989 B1 “Oximetric tonometer with intracranial pressure monitoring capability” May 21, 2002, Patent priority date June 19, 1998, Denninghoff KR
2. US 6,244,712 “Optical Scanning Spectroscopic Apparatus and Associated Method” September 27, 1999, Smith MH, Hillman LW, Denninghoff KR
3. 60/312,187 “Multispectral Image Processing Method, Apparatus and Computer Program Product for Determining the Blood Oxygen Saturation in a Vessel” August 14, 2001, Smith, MH, Hillman, LW, Denninghoff KR
4. 6,701,169, PCT/US00/11466 “Method of determining autoregulatory and perfusion status” March 2, 2004, Denninghoff KR
5. US 5,935,076 Method and apparatus for accurately measuring the transmittance of blood within a retinal vessel, August 10, 1999, Smith MH, Chipman RA, Hillman LW, Denninghoff KR, Minnich TE
6. 10/134,360 “Method and Apparatus for Measuring Blood Oxygen Saturation in a Retinal Vessel by Separately Detecting Single Pass Optical Signals” April 2002 Smith MH, Hillman, LW, Denninghoff, KR Lompado, A
7. PCT submitted 5/2006 “Method for calibrated measurement of oxygen saturation and hematocrit in whole blood” Denninghoff, KR, Hillman, LW
Sponsored Research Through MSRP: 
Patricia Olaya (MSRP 2006): "Polyamines and their Acetyl Derivatives as Biomarkers for Urinary Tract Infections."
Albert Langa (MSRP 2007): "Hydroxocobalamin Therapy and Hemoglobin Spectra."
Brendan Munzer (MSRP 2010): "Comparison of Pulse Pressure Variation (PPV) to Other Monitoring Strategies in the Fluid Optimization of Patients with Sepsis."
Katrina Voss (MSRP 2012): "Use of Retinal Oximeter to Guide Early Goal-Directed Therapy in a Swine Model of Severe Sepsis and Septic Shock"
Darin Liu (MSRP 2014): "Use of a Retinal Oximeter to Guide Early Goal-Directed Therapy in a Swine Model of Severe Sepsis and Septic Shock"
Advanced Research Distinction Track (RDT): 
Tyler Durns, (RDT Class of 2017): "Presenting Illness and Mortality Outcomes in Patients Intubated in the Emergency Department"
NIH Undergraduate Diversity Program: 
Juan Benjamin, 2012, 2014 "Image Acquisition and Analysis of Retinal Oximetry"
Fernando Tapia, 2013, 2014 "Establishing Validity of Retinal Oximetry in Experimental Swine Model"
NIH High School Student Research Program: 
-David Garcia, Desert View High School, 2007
-Robert Shatto, Douglas High School, 2008
Wednesday, August 30, 2017