Professor, Emergency Medicine
Professor, Optical Sciences
Professor, BIO5 Institute
Professor, Optical Sciences
Professor, BIO5 Institute
Education:
- Vanderbilt University, 1983 (BS, Biomedical and Electrical Engineering)
- Vanderbilt University School of Medicine, 1987 (MD)
- Charity Hospital, New Orleans, 1987-1988 (Internship, General Surgery)
- Charity Hospital, New Orleans, 1988-1991 (Residency, Emergency Medicine)
Honors and Awards:
- Award for “Significant Contributions to Research in Emergency Medicine” the University of Alabama at Birmingham, Department of Emergency Medicine, 2005
- Winner of the Pascal Rol Award for Excellence in Ophthalmic Technologies at the SPIE 2001 National Meeting, 2001
- Outstanding Scholars of the 21st Century, International Biographical Center, Cambridge, England, 2001,2000
- Marquis Who's Who in Science and Engineering, 1999
- Resident Research Competition, Southern Medical Association, 1991
- Biomedical Engineering Award "Judged by the program faculty to have made the greatest progress in professional development as an undergraduate", Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, 1983
- Tau Beta Pi, Engineering Honorary Society, 1983
- Eta Kappa Nu, Electrical Engineering Honorary Society, 1983
Selected Publications:
Denninghoff KR: “Enrollment of sudden cardiac death victims into a limited cardiac autopsy study in the emergency department: The effects of race” Journal of the National Medical Association. Vol. 92 (1) 36-38, January, 2000.
Smith MH, Denninghoff KR, Lompado A, Hillman LW: “Effect of multiple light paths on retinal vessel oximetry” Applied Optics. 39(7):1183-1193, March, 2000.
McNutt S, Denninghoff KR, Terndrup T: Shock: “Rapid recognition and appropriate ED intervention” Emergency Medicine Practice. Vol. 2 (8) 1-24, August, 2000.
Denninghoff KR, Smith MH: “Optical model of the blood in the large retinal vessels” Journal of Biomedical Optics, Vol. 5 (4) 1-4, October, 2000.
Denninghoff, KR, Smith, MH, Lompado, A, Hillman, LW: “Retinal venous oxygen saturation and cardiac output during controlled hemorrhage and resuscitation” J Appl Physiol 94, 891-896, March, 2003
Salyer, DA, Beaudry, N, Basavanthappa, S, Twietmeyer, K, Eskandari, M, Denninghoff, KR, Chipman, RA, Park, RI. “Retinal oximetry using intravitrial illumination” Curr Eye Res 31(7-8):617-27, 2006
Denninghoff, KR, Chipman, RA, Hillman, LW: “Oxyhemoglobin Saturation Measurements by Green Spectral Shift” Opt Lett 31(7), 924-926, April, 2006
Denninghoff, KR, Chipman, RA, Hillman, LW: Blood Oxyhemoglobin Saturation Measurements by Blue Green Spectral Shift, Accepted for publication by The Journal of Biomedical Optics 2/2007
Patents:
- US 6,390,989 B1 “Oximetric tonometer with intracranial pressure monitoring capability” May 21, 2002, Patent priority date June 19, 1998, Denninghoff KR
- US 6,244,712 “Optical Scanning Spectroscopic Apparatus and Associated Method” September 27, 1999, Smith MH, Hillman LW, Denninghoff KR
- 60/312,187 “Multispectral Image Processing Method, Apparatus and Computer Program Product for Determining the Blood Oxygen Saturation in a Vessel” August 14, 2001, Smith, MH, Hillman, LW, Denninghoff KR
- 6,701,169, PCT/US00/11466 “Method of determining autoregulatory and perfusion status” March 2, 2004, Denninghoff KR
- US 5,935,076 Method and apparatus for accurately measuring the transmittance of blood within a retinal vessel, August 10, 1999, Smith MH, Chipman RA, Hillman LW, Denninghoff KR, Minnich TE
- 10/134,360 “Method and Apparatus for Measuring Blood Oxygen Saturation in a Retinal Vessel by Separately Detecting Single Pass Optical Signals” April 2002 Smith MH, Hillman, LW, Denninghoff, KR Lompado, A
- PCT submitted 5/2006 “Method for calibrated measurement of oxygen saturation and hematocrit in whole blood” Denninghoff, KR, Hillman, LW
Sponsored Research Through MSRP:
Patricia Olaya, (MSRP 2006): "Polyamines and their Acetyl Derivatives as Biomarkers for Urinary Tract Infections."
Albert Langa, (MSRP 2007): "Hydroxocobalamin Therapy and Hemoglobin Spectra."
Brendan Munzer, (MSRP 2010): "Comparison of Pulse Pressure Variation (PPV) to Other Monitoring Strategies in the Fluid Optimization of Patients with Sepsis."
Katrina Voss, (MSRP 2012): "Use of Retinal Oximeter to Guide Early Goal-Directed Therapy in a Swine Model of Severe Sepsis and Septic Shock"
Darin Liu, (MSRP 2014): "Use of a Retinal Oximeter to Guide Early Goal-Directed Therapy in a Swine Model of Severe Sepsis and Septic Shock"
Advanced Research Distinction Track (RDT):
Tyler Durns, (RDT Class of 2017): "Presenting Illness and Mortality Outcomes in Patients Intubated in the Emergency Department"
NIH Undergraduate Diversity Program:
Juan Benjamin, 2012, 2014 "Image Acquisition and Analysis of Retinal Oximetry"
Fernando Tapia, 2013, 2014 "Establishing Validity of Retinal Oximetry in Experimental Swine Model"
NIH High School Student Research Program:
David Garcia, Desert View High School, 2007
Robert Shatto, Douglas High School, 2008
Wednesday, August 30, 2017