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Scott E. Klewer, MD

Professor, Pediatrics
Professor, Cellular and Molecular Medicine
Professor, Medicine

PO Box 245073
Building: Arizona Health Sciences Center (#201)
Room #: 3302

Fax: (520)626-6571

(520) 626-5585
sklewer@peds.arizona.edu

Selected Publications

Klewer SE, Yatskievych T, Pogreba K, Stevens MV, Antin PB, Camenisch TD. Has2 expression in heart forming regions is independent of BMP signaling. Gene Expr Patterns. 2006 (E-publication).
 
Person AD. Klewer SE. Runyan RB. Cell biology of cardiac cushion development. International Review of Cytology. 243:287-335, 2005.
 
Person AD. Garriock RJ. Krieg PA. Runyan RB. Klewer SE. Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development. Developmental Biology. 278(1):35-48, 2005.
 
Gittenberger-de Groot AC. Bartram U. Oosthoek PW. Bartelings MM. Hogers B. Poelmann RE. Jongewaard IN. Klewer SE. Collagen type VI expression during cardiac development and in human fetuses with trisomy 21. Anatomical Record. Part A, Discoveries in Molecular, Cellular, & Evolutionary Biology. 275(2):1109-16, 2003.
 

Sponsored Research Through MSRP

Sam Pak, (MSRP 1997): "Characterization of the temporal expression patterns of a novel gene, D-7, in embryonic mouse development."
 
Gregory Middleton, (MSRP 2005): "Non-invasive assessment of children with palliated single-ventricle heart defects using the radial artery contour."
 
Charity Jackson (MSRP 2005): "Duration of chest pain in a pediatric population."
 
Sean Behan, (MSRP 2015; "A Socioeconomic Analysis of Adults Living with a Congenital Heart Defect: Tetralogy of Fallot in a Diverse Patient Population"
 
Sylvestor (Sammy) Moses, (MSRP 2016) "Fontan Physiology and Fontan Complications in Children with Univentricular Heart Disease."
 
Asim Zehri, (MSRP 2018): "Identifying Factors Associated with Loss to Follow-up in Patients with Adult Congenital Heart Disease."
 
Vanessa Eller, (MSRP 2020): "The Correlation Between Executive Function, Coping mechanisms, and Brain Structure in Individuals with CHD"
 
Christie Rosputni, (MSRP 2020): "Genetic Determinants of Variable Expressivity of Obstructive Left Heart Disease"
 

Advanced Research Distinction Track (RDT)

Sean Behan, (RDT Class of 2018): "A Socioeconomic Analysis of Adults Living with a Congenital Heart Defect: Tetralogy of Fallot in a Diverse Patient Population"
 
Chelsea Takamatsu, (RDT Class of 2020): "Reproductive Health of Females with Congenital Heart Defects"
 
Vanessa Eller, (RDT Class of 2023): "Executive Function, Maladaptive Coping, and Mental Health Outcomes In Young Adults With Congenital Heart Defects"
 
Christie Rosputni, (RDT Class of 2023): "Genetic Determinants of Variable Expressivity of Obstructive Left Heart Disease"
 

NIH High School Student Research Program

Lilian Gomez, Tucson Junior Academy, 1997
Kai Loughlin, Corona del Sol High School, 1999
Elissa Eller, Xavier College Prep, 2003

Degrees

  • Arizona State University 1987 (B.S.)
  • University of Arizona, 1991 (M.D.)
  • University of Iowa Hospitals & Clinics, Iowa City, Iowa, 1991-1993 (Residency, Pediatrics)
  • University of Iowa Hospitals & Clinics, Iowa City, Iowa, 1993-1996 (Fellowship, Pediatric Cardiology)

Awards

  • University Medical Center Chief of Staff 2009-2011

Research Interests

Dr. Klewer, a professor in The University of Arizona Department of Pediatrics, is a 1991 graduate of the UA College of Medicine. He completed his pediatric residency and a fellowship in pediatric cardiology at the University of Iowa. He is board certified in pediatric cardiology.

Dr. Klewer’s specialty is providing medical care to children with heart problems, and his particular expertise is in the non-invasive imaging of the heart. In addition to caring for patients and teaching medical students and residents, Dr. Klewer is an active researcher in the Sarver Heart Center and the Steele Children’s Research Center, where he is an associate director. He and his research team currently are investigating bicuspid aortic valve (BAV), the most common congenital heart defect, affecting about 3 percent of the population.

His research topics include:
Molecular and genetic analysis of cardiovascular development with an emphasis on role of the extracellular matrix in heart valve formation and blood vessel morphogenesis.
Molecular pathways directing normal and abnormal heart valve development in order to improve the diagnosis and repair of severe congenital heart defects and to understand the development of the human heart, to understand at what point the heart can begin to develop abnormally. Of particular concern are babies who are born with Down syndrome as nearly half of these babies also are born with significant heart defects.