Lalitha Madhavan, MD, PhD
Professor, Neurology
Professor, Evelyn F Mcknight Brain Institute
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
Professor, Medicine
Professor, Neuroscience
Professor, Physiological Sciences
Professor, Clinical Translational Sciences
Professor, Applied BioSciences
Member of the General Faculty
Member of the Graduate Faculty
PO Box 5023
Building: Arizona Health Sciences Center (#201)
Room #: 6131
Links
Selected Publications
Corenblum, M. J., Flores, A. J., Badowski, M., Harris, D. T., & Madhavan, L. (2015). Systemic human CD34(+) cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration. Regenerative medicine, 10(5), 563-77.
Madhavan, L. (2015). Redox-based regulation of neural stem cell function and Nrf2. Biochemical Society transactions, 43(4), 627-31.
Madhavan, L., Daley, B. F., Davidson, B. L., Boudreau, R. L., Lipton, J. W., Cole-Strauss, A., Steece-Collier, K., & Collier, T. J. (2015). Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PloS one, 10(9), e0137136.
Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B., Celano, S. L., Green, J. J., Imus, N. M., Marckini, N., Daley, B., Steece-Collier, K., & Collier, T. J. (2015). Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 874-83.
Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B., Daley, B. F., & Collier, T. J. (2015). Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system. Experimental neurology, 266, 11-21.
Gombash, S. E., Lipton, J. W., Collier, T. J., Madhavan, L., Steece-Collier, K., Cole-Strauss, A., Terpstra, B. T., Spieles-Engemann, A. L., Daley, B. F., Wohlgenant, S. L., Thompson, V. B., Manfredsson, F. P., Mandel, R. J., & Sortwell, C. E. (2012). Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular therapy : the journal of the American Society of Gene Therapy, 20(3), 544-54.
NIH Undergraduate Diversity Program
Samar Iftikhar, 2017, "How do we study Parkinson’s disease?"
Luke Dreher, 2019, "Interactions between Alpha-synuclein and Nrf2 in the context of Parkinson’s Disease"
NIH High School Student Research Program
Justine Davis, Red Mountain High School, 2016
Nhat Nguyen, Catalina Magnet High School, 2017
Degrees
- Baroda Medical College, Vadodara, India (M.D.)
- Neuroscience, Iowa State University, Ames, IA (Ph.D)
Research Interests
Broad Interests: Neuroscience and Stem Cell BiologySpecific Interests: Aging and Neurodegeneration, Role of endogenous neural stem cells in development and disease, Graft-host interactions after neural transplantation, Central nervous system plasticity and regeneration, Disease modeling using patient-specific iPS cells and their derivatives.