Tally Largent-Milnes, PhD

Associate Professor, Pharmacology
Assistant Professor, BIO5 Institute

Education:

University of Arizona, Neurokinin 1 receptors and their role in opioid-induced hyperalgesia, antinociceptive tolerance, and reward (Ph.D., Medical Pharmacology)
University of Arizona, Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling (B.S., Biochemistry and Molecular Biophysics, Molecular and Cellular Biology)

Honors and Awards:

Individual NRSA Fellowship (F32DE022499), National Institutes of Health, Fall 2011
Research selected for “Hot Topics” media material, Society for Neuroscience, Fall 2009
Travel Award, International Association for the Study of Pain, Summer 2008
Donald G. Sheer Memorial Travel Award, University of Arizona, Spring 2008
Graduate Fellowship, University of Arizona, Graduate College, Department of Pharmacology, Fall 2007
Graduate and Professional Student Council Travel Award, University of Arizona, Fall 2007

Major Areas of Research Interest:

Understand neuroscience, physiology, and pharmacology to enhance drug discover and delivery to better manage chronic pain

Selected Publications:

Deekonda, S., Cole, J., Sunna, S., Rankin, D., Largent-Milnes, T. M., Davis, P., BassiriRad, N. M., Lai, J., Vanderah, T. W., Porecca, F., & Hruby, V. J. (2016). Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & medicinal chemistry letters, 26(1), 222-7.

Forte, B. L., Slosky, L. M., Zhang, H., Arnold, M. R., Staatz, W. D., Hay, M., Largent-Milnes, T. M., & Vanderah, T. W. (2016). Angiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain. Pain, 157(12), 2709-2721.

Grenald, S. A., Young, M. A., Wang, Y., Ossipov, M. H., Ibrahim, M. M., Largent-Milnes, T. M., & Vanderah, T. W. (2016). Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists. Neuropharmacology, 116, 59-70.

Ramos-Colon, C. N., Lee, Y. S., Remesic, M., Hall, S. M., LaVigne, J., Davis, P., Sandweiss, A. J., McIntosh, M. I., Hanson, J., Largent-Milnes, T. M., Vanderah, T. W., Streicher, J., Porreca, F., & Hruby, V. J. (2016). Structure-Activity Relationships of [des-Arg(7)]Dynorphin A Analogues at the κ Opioid Receptor. Journal of medicinal chemistry, 59(22), 10291-10298.

Slosky, L. M., BassiriRad, N. M., Symons, A. M., Thompson, M., Doyle, T., Forte, B. L., Staatz, W. D., Bui, L., Neumann, W. L., Mantyh, P. W., Salvemini, D., Largent-Milnes, T. M., & Vanderah, T. W. (2016). The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain. Pain, 157(11), 2605-2616.

Deekonda, S., Wugalter, L., Kulkarni, V., Rankin, D., Largent-Milnes, T. M., Davis, P., Bassirirad, N. M., Lai, J., Vanderah, T. W., Porreca, F., & Hruby, V. J. (2015). Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & medicinal chemistry, 23(18), 6185-94.

Deekonda, S., Wugalter, L., Rankin, D., Largent-Milnes, T. M., Davis, P., Wang, Y., Bassirirad, N. M., Lai, J., Kulkarni, V., Vanderah, T. W., Porreca, F., & Hruby, V. J. (2015). Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & medicinal chemistry letters, 25(20), 4683-8.

Fawley, J. A., Hofmann, M. E., Largent-Milnes, T. M., & Andresen, M. C. (2015). Temperature differentially facilitates spontaneous but not evoked glutamate release from cranial visceral primary afferents. PloS one, 10(5), e0127764.

François-Moutal, L., Wang, Y., Moutal, A., Cottier, K. E., Melemedjian, O. K., Yang, X., Wang, Y., Ju, W., Largent-Milnes, T. M., Khanna, M., Vanderah, T. W., & Khanna, R. (2015). A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain, 156(7), 1247-64.

Giri, A. K., Apostol, C. R., Wang, Y., Forte, B. L., Largent-Milnes, T. M., Davis, P., Rankin, D., Molnar, G., Olson, K. M., Porreca, F., Vanderah, T. W., & Hruby, V. J. (2015). Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of medicinal chemistry, 58(21), 8573-83.

Slosky, L. M., Largent-Milnes, T. M., & Vanderah, T. W. (2015). Use of Animal Models in Understanding Cancer-induced Bone Pain. Cancer growth and metastasis, 8(Suppl 1), 47-62.

Grenald, S. A., Largent-Milnes, T. M., & Vanderah, T. W. (2014). Animal models for opioid addiction drug discovery. Expert opinion on drug discovery, 9(11), 1345-54.

Hegarty, D. M., Hermes, S. M., Largent-Milnes, T. M., & Aicher, S. A. (2014). Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats. Journal of chemical neuroanatomy, 61-62, 1-12.

Hofmann, M. E., Largent-Milnes, T. M., Fawley, J. A., & Andresen, M. C. (2014). External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1. Journal of neurophysiology, 112(11), 2697-706.

Largent-Milnes, T. M., Hegarty, D. M., Aicher, S. A., & Andresen, M. C. (2014). Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons. Journal of neurophysiology, 111(11), 2222-31.

Largent-Milnes, T. M., Brookshire, S. W., Skinner, D. P., Hanlon, K. E., Giuvelis, D., Yamamoto, T., Davis, P., Campos, C. R., Nair, P., Deekonda, S., Bilsky, E. J., Porreca, F., Hruby, V. J., & Vanderah, T. W. (2013). Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of pharmacology and experimental therapeutics, 347(1), 7-19.

Lozano-Ondoua, A. N., Hanlon, K. E., Symons-Liguori, A. M., Largent-Milnes, T. M., Havelin, J. J., Ferland, H. L., Chandramouli, A., Owusu-Ankomah, M., Nikolich-Zugich, T., Bloom, A. P., Jimenez-Andrade, J. M., King, T., Porreca, F., Nelson, M. A., Mantyh, P. W., & Vanderah, T. W. (2013). Disease modification of breast cancer-induced bone remodeling by cannabinoid 2 receptor agonists. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 28(1), 92-107.

Nair, P., Yamamoto, T., Largent-Milnes, T. M., Cowell, S., Kulkarni, V., Moye, S., Navratilova, E., Davis, P., Ma, S., Vanderah, T. W., Lai, J., Porreca, F., & Hruby, V. J. (2013). Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & medicinal chemistry letters, 23(17), 4975-8.

Marshall, T. M., Herman, D. S., Largent-Milnes, T. M., Badghisi, H., Zuber, K., Holt, S. C., Lai, J., Porreca, F., & Vanderah, T. W. (2012). Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord. Pain, 153(1), 86-94.

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