Kenneth Ramos, MD, PhD, PharmB

Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Internal Medicine
Associate Vice President for Precision Health Sciences, Research
Director, Center for Applied Genetics and Genomic Medicine
Director, MD-PhD Program
Additional Contact Info: 
Vera Madril/Coordinator
BS: University of Puerto Rico, Pharmaceutical Sciences and Chemistry, with Highest Honors
MD: University of Louisville Health Sciences Center
PhD: University of Texas at Austin, Biochemical Pharmacology
University of Louisville Health Sciences Center, Internal Medicine & Pulmonology
Honors and Awards: 
  • President, Society of Toxicology
  • President, The American Heart Association Texas
  • Member, Society for In Vitro Biology
  • Member, American Association for the Advancement of Science
  • Member, American Society for Cell Biology
  • Member, American Society for Pharmacology and Experimental Therapeutics
  • Member, American College of Forensic Examiners
  • Member, North American Vascular Biology Organization
  • Member, American Society for Biochemistry and Molecular Biology
  • Member, Association of Medical and Graduate Departments of Biochemistry
  • Member, American Medical Association
  • Member, American College of Physicians and International Association of Internists
Major Areas of Research Interest: 

 genomics, precision medicine and toxicology, internal medicine and pulmonology

Research Activities: 

Dr. Ramos is recognized as a leading expert in the study of gene-gene and gene-environment interactions and genomic medicine. His research program integrates diverse approaches, ranging from molecular genetics to population-based public health studies in efforts to understand the genetic and genomic basis of human disease and to advance the goals of precision medicine. Ongoing basic science studies in his laboratory focus on repetitive genetic elements in the mammalian genome and their role in genome plasticity and disease, while his clinical work focuses on the characterization of diagnostic and prognostic biomarkers for chronic disease and cancer.

He has mentored 100 doctoral, medical, veterinary medicine, undergraduate and high school students, many of whom have gone on to successful careers in academia, medicine, government and industry. He is committed to initiatives that attract and retain minorities in science and medicine.

Selected Publications: 

Malanga, S.E, Loe, J.D., Robertson, C.T. and Ramos, K.S. Big data neglects populations most in need of medical and public health research and intervention.  Law and Society: Public Law –Poverty eJournal, 2016.

Alsaid, N., Ramos, K.S., Sweitzer, N., Slack, M., Erstad, B., Gharaibeh, M., Klimecki, W., Larriva, M., Karnes, J., Abraham, I. Pharmacoeconomic impact of Arg-389 genetic testing on bucindolol treatment decisions in stages III/IV heart failure. Submitted, 2016.
Hosseinnejad, K., Bailen, J.L., Isaacs, L., Ramos, K.S. and Jortani, S.E. Open Reading Frame 1 (ORF1) protein serum concentrations in men with prostate cancer. Clinical Chemistry, 2016.
Aispuro, I.O., Reyes-Reyes, E.M., Santa Cruz, M. Ramos, KS. Long interspersed nuclear element-1 regulates malignant transformation of lung bronchial epithelial cells through epithelial-to-mesenchymal transition. American Association for Cancer Research: Targeting the Vulnerabilities of Cancer, 2016.
Bojang, P. and Ramos, K.S. Induction of L1 retroelement in human bronchial epithelial cells by tobacco carcinogens. American Thoracic Society, 2016.
Jortani, S.A., Hosseinnejadl, K., Mains, A., Guerra, S., Vazquez, M., Bojang, P. and Ramos, K.S. Identification of the long interspersed nuclear element-1 (L1) product in human plasma as an epigenetic biomarker of environmentally induced disease. Clinical Chemistry, 2015.
Bojang, P., Gao, H., Haeberle, M.T and Ramos, K.S.. Epithelial-to-mesenchymal Transition in Human BEAS and BZR Cells by Benzo(a)pyrene: Involvement of Aryl Hydrocarbon Receptor and Long Interspersed Nuclear Element-1.  Toxicological Sciences, 2014.
Yeager II, R., DeJarnett, N., Conklin, D., Tollerud, D.J., Abplanalp, W., O’Toole, T., Myers, J.D., Ramos, K., Lee, J., McCraken, J., Srivastava, S., Hamzeh, I., Wagner, S., Chugh, A., Defilippis, A., Becher, C., Higdon, D., Wyatt, B., Ciszewski, T., Riggs, D., Bhatnagar, A.  Levels of early circulating angiogenic cells associated with geographic metrics of roadway exposure. American Journal of Public Health, 2014.
DeJarnett, N., Conklin, D., Riggs, D., O’Toole, T., McCraken, J., Abplanalp, W., Haberzett, P., Yeager, R., Srivastava, S., Hamzeh, I., Wagner, S., Chugh, A., Defilippis, A., Ciszeski, T., Wyatt, B., Becher, C., Higdon, D., Xie, Z., Ramos, K., Tollerud, D.J., Myers, J.A., Rai, S., Prabhu, S. and Bhatnagar, A.  Association between benzene exposure, circulating angiogenic cell levels and cardiovascular risk in the Louisville Health Heart Study.  American Journal of Public Health, 2014.
Huang, T., Toth, E., Boyang, P., Ramos, K, Camenisch, T. Activation of Line1 retrotransposon by arsenic:  A novel mechanism of genomic damage and instability. Toxicological Sciences, 2015.
Sponsored Research Through MSRP: 
Samwel Ochieng (MSRP 2017); "Impact of Epigenetic Drugs on Driver Mutations in Lung Cancer"
NIH Undergraduate Diversity Program: 
Stephanie Galvez (2016): Influence of Autophagy/Kinase Inhibitor (LY294002) On Line-1 (L1) Expression and Retrotransposition  
NIH High School Student Research Program: 
Minerva Santa Cruz (2015) Desert View High School
Shane Campillo (2016) Baboquivari High School
Wednesday, March 7, 2018