Jason X.-J. Yuan, MD, PhD

Professor, Medicine
Associate Vice President, Translational Health Sciences
Chief, Division of Translational Regenerative Medicine
Professor, Physiology
Professor, Physiological Sciences - GIDP

MD: Suzhou Medical College, Suzhou, China, 1983
PhD: Peking Union Medical College, Beijing, China, 1993

Honors and Awards: 
Established Investigator Award, American Heart Association
Pulmonary Vascular Research Institute Achievement Award
Guggenheim Fellowship Award, 2008
Patent co-holder, “Regulating Expression of Transient Receptor Potential Channel Genes,” with C.V. Remillard, L.J. Rubin and Y. Yu
Member, American Thoracic Society, 1989
Fellow, American Physiological Society, 1989
Fellow, American Association for the Advancement of Science, 1993
Fellow, American Heart Association, 2003
Elected Member, American Society for Clinical Investigation, 2007
Elected Member, Association of American Physicians, 2013
Major Areas of Research Interest: 

As a physician-scientist, Dr. Yuan’s research interests include pulmonary vascular pathophysiology and pathogenic mechanisms of pulmonary vascular disease, including idiopathic pulmonary arterial hypertension, chronic thromboembolic pulmonary hypertension, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis, obstructive sleep apnea, sickle cell disease and scleroderma.

Selected Publications: 

 Kumar, S., Sun, X., Noonepalle, S. K., Lu, Q., Zemskov, E., Wang, T., Aggarwal, S., Gross, C., Sharma, S., Desai, A. A., Hou, Y., Dasarathy, S., Qu, N., Reddy, V., Lee, S. G., Cherian-Shaw, M., Yuan, J. X., Catravas, J. D., Rafikov, R., , Garcia, J. G., et al. (2017). Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. Free radical biology & medicine, 102, 217-228.

Ayon, R. J., Tang, H., & Yuan, J. X. (2016). Gasping for answers. Editorial Focus on "Calpain Activation by ROS mediates Human ether-a-go-go-related gene Protein Degradation by Intermittent Hypoxia". American journal of physiology. Cell physiology, ajpcell.00017.2016.

Boehme, J., Sun, X., Tormos, K. V., Gong, W., Kellner, M., Datar, S. A., Kameny, R. J., Yuan, J. X., Raff, G. W., Fineman, J. R., Black, S. M., & Maltepe, E. (2016). Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation. American journal of physiology. Heart and circulatory physiology, 311(4), H944-H957.

Chen, T., Zhou, Q., Tang, H., Bozkanat, M., Yuan, J. X., Raj, J. U., & Zhou, G. (2016). miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. Journal of the American Heart Association, 5(12).
Jiang, Q., Lu, W., Yang, K., Hadadi, C., Fu, X., Chen, Y., Yun, X., Zhang, J., Li, M., Xu, L., Tang, H., Yuan, J. X., Wang, J., & Sun, D. (2016). Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. American journal of physiology. Cell physiology, 311(1), C136-49.

Rafikova, O., Meadows, M. L., Kinchen, J. M., Mohney, R. P., Maltepe, E., Desai, A. A., Yuan, J. X., Garcia, J. G., Fineman, J. R., Rafikov, R., & Black, S. M. (2016). Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PloS one, 11(3), e0150480.

NIH Undergraduate Diversity Program: 

Marisela Rodriguez, 2015, "Role of Ca2++ in Pulmonary Hypertension"

Nadia Ingabire, 2016: "Role of the Transcription Factor Snai1 and Snai2 in Endothelial to Mesenchymal Transition?"

Ciara Lugo, 2016: "Effect of Ethnicity on Pulmonary Hypertension"

NIH High School Student Research Program: 
Kimberly Henderson, Nogales High School, 2013
Savannah Brown, Salpointe Catholic High School, 2015
Nadia Ingabire, Desert View High School, 2015
Charles Henderson, Tuba City High School, 2016
Rodrigo Villarreal Hernandez, Tucson High School, 2016
Mario Ibarra, Amphitheater High School, 2017
Wednesday, August 30, 2017