Professor Emeritus of Biochemistry and Molecular Biophysics
Professor Emeritus, Arizona Research Laboratories
Professor Emeritus of Neuroscience
- B.S. 1960, University of North Dakota
- M.S. 1962, University of North Dakota
- Ph.D. 1965, Cornell University
- Studies on the design, synthesis and pharmacological evaluation of novel, multivalent ligands for the treatment of prolonged and neuropathic pain without toxicities or the developing of tolerance.
- Studies of the synthesis of multivalent ligands with reporter groups and/or drugs for the detection and/or treatment of cancer
- Development of melanotropin hormone and neurotransmitter analogues with biological activity profiles for the treatment of feeding disorders, pigmentary disorders, sexual disorders, pain, and immune or inflammatory responses
I.D. Alves, Z. Salamon, E. Varga, H.I. Yamamura, G. Tollin, and V.J. Hruby. Direct Observation of G-Protein Binding to the Human Œ¥-Opioid Receptor Using Plasmon-Waveguide Resonance Spectroscopy. J. Biol. Chem., 278, 48890-48897 (2003).
M. Cai, M. Stankova, S. J.K. Pond, A.V. Mayorov, J.W. Perry, H.I. Yamamura, D. Trivedi, and V.J. Hruby. Real Time Differentiation of G-Protein Coupled Receptor (GPCR) Agonist and Antagonist by Two Photon Fluorescence Laser Microscopy. J. Am. Chem. Soc., 126, 7160-7161 (2004).
M. Cai, A.V. Mayorov, C. Cabello, M. Stankova, D. Trivedi, and V.J. Hruby. Novel 3D Pharmacophore of Œ±-MSH/Œ≥-MSH Hybrids Leads to Selective Human MC1R and MC3R Analogues. J. Med. Chem., 48, 1839-1848 (2005).
J.P. Cain, A.V. Mayorov, M. Cai, H. Wang, B. Tan, K. Chandler, Y.S. Lee, R.R. Petrov, D. Trivedi, and V.J. Hruby. Design, Synthesis, and Biological Evaluation of a New Class of Small Molecule Peptide Mimetics Targeting the Melanocortin Receptors.
Bioorg. Med. Chem. Letts., 16, 5462-5467 (2006). PMC1810397
V.J. Hruby, M. Cai, J.P. Cain, A.V. Mayorov, M.M. Dedek, and D. Trivedi. Design, Synthesis and Biological Evaluation of Ligands Selective for the Melanocortin-3 Receptor. Current Topics Med. Chem., 7, 1085-1097 (2007). PMC2274922
A.V. Mayorov, M. Cai, E.S. Palmer, M.M. Dedek, J.P. Cain, A.R. Van Scoy, B. Tan, J. Vagner, D. Trivedi, and V.J. Hruby. Structure-Activity Relationships of Cyclic Lactam Analogues of Œ±-Melanocyte-Stimulating Hormone (Œ±-MSH) Targeting the Human Melanocortin-3 Receptor. J. Med. Chem., 51, 187-195 (2008). PMC2587288
Y.S. Lee, R.S. Agnes, J.P. Cain, V. Kulkarni, M. Cai, C. Salibay, K. Ciano, R. Petrov, A. Mayorov, J. Vagner, D. Trivedi, P. Davis, S-W. Ma, J. Lai, F. Porreca, R. Vardanyan, and V.J. Hruby. Opioid and Melanocortin Receptors: Do They Have Overlapping Pharmacophores? Peptide Science, 90, 433-438 (2007). PMC2693099
L. Doedens, F. Opperer, M. Cai, J.G. Beck, M. Dedek, E. Palmer, V.J. Hruby, and H. Kessler Multiple N-Methylationof MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies J. Amer. Chem. Soc., 132, 8115-8128 (2010). NIHMSID 208710.
D. Torino, A. Mollica, F. Pinnen, F. Feliciani, G. Lucente, G. Fabrizi, G. Portalone, P. Davis, J. Lai, S-W. Ma, F. Porreca, and V.J. Hruby Synthesis and Evaluation of New Endomorphin-2 Analogues Containing (Z)-Œ±,Œ≤-Didehydrophenylalanine (ŒîZPhe) Residues. J. Med. Chem. 53 (11), 4550–4554 (2010).
J.S. Josan, H.L. Handl, R Sankanaryanan, L. Xu, R.M. Lynch, J. Vagner, E.A. Mash, V.J. Hruby and R.J. Gillies. Cell Specific Targeting by Heterovalent Ligands. Bioconjugate Chemistry, 22, 1270-1278 (2011)
Kimberly Hill (MSRP 2012): " Elucidation of Dynorphin a Action at Bradykinin Receptors in CNS and Drug Design for Antagonists at Said Receptors."
-Joshua Carlin, Basis North High School, 2015