Patrick T. Ronaldson, PhD

Professor, Pharmacology
Professor, Neuroscience
Professor, Physiological Sciences
Chair, Neuroscience 
 
Education: 
  • University of Toronto, Ontario, Canada (Ph.D., Pharmaceutical Sciences)

Functional expression of ATP-binding cassette (ABC) transporters in brain cellular compartments and in glial cells exposed to HIV-1 viral proteins.

  • University of Toronto, Toronto, Ontario, Canada (Honours B.Sc. Pharmacology)
Honors and Awards: 
  • Pharmacokinetics, Pharmacodynamics, and Drug Metabolism (PPDM) Section Service Award
  • American Association of Pharmaceutical Scientists (AAPS) Fall 2016
Major Areas of Research Interest: 
  • Ischemic Stroke
  • Blood-Brain Barrier
  • Mechanisms of Drug Transport across Biological Membranes
  • Regulation of Drug Transport Processes
  • CNS Drug Delivery; Vascular Protection
  • Drug-Drug Interactions
Selected Publications: 
Chapters
 
Ronaldson, P. T., & Davis, T. P. (2016). Glial support of blood-brain barrier integrity: Molecular targets for novel therapeutic strategies in stroke. In Non-neural mechanisms of brain damage and repair after stroke(pp 45-80). Switzerland: Springer International Publishing. doi:10.1007/978-3-319-32337-4
 
Ronaldson, P. T., & Davis, T. P. (2016). Mechanisms of Endothelial Injury and Blood-Brain Barrier Dysfunction in Stroke. In Caplan Primer on Cerebrovascular Diseases, 2nd Edition(pp TBD). Philadelphia, PA: Elsevier Inc.
 
Journals/Publications
 
Abdullahi, W., Brzica, H., Ibbotson, K., Davis, T. P., & Ronaldson, P. T. (2017). Bone Morphogenetic Protein-9 Increases Expression of Organic Anion Transporting Polypeptide 1a4 at the Blood-Brain Barrier via the Activin Receptor-Like Kinase-1 Receptor. Journal of Cerebral Blood Flow and Metabolism, 37(7), 2340-2345. doi:10.1177/0271678X17702916
 
Abdullahi, W., Davis, T. P., & Ronaldson, P. T. (2017). Functional Expression of P-glycoprotein and Organic Anion Transporting Polypeptides at the Blood-Brain Barrier: Understanding Transport Mechanisms for Improved CNS Drug Delivery?. The AAPS journal, 19(4), 931-939. doi:10.1208/s12248-017-0081-9
 
Brzica, H., Abdullahi, W., Ibbotson, K., & Ronaldson, P. T. (2017). Role of Transporters in CNS Drug Delivery and Blood-Brain Barrier Protection: Relevance to Treatment of Stroke. Journal of Central Nervous System Diseases, 9, 1-12. doi:10.1177/1179573517693802
 
Ibbotson, K., Yell, J. A., & Ronaldson, P. T. (2017). Nrf2 Signaling Increases Expression of ATP-Binding Cassette Subfamily C mRNA Transcripts at the Blood-Brain Barrier following Hypoxia-Reoxygenation Stress. Fluids and Barriers of the CNS, 14(1), 6. doi:10.1186/s12987-017-0055-4
 
Lochhead, J. J., Ronaldson, P. T., & Davis, T. P. (2017). Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System. The AAPS journal, 19(4), 910-920. doi:10.1208/s12248-017-0076-6
 
Ronaldson, P. T., Bauer, B., El-Kattan, A. F., Shen, H., Salphati, L., & Louie, S. W. (2016). Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations. Clinical pharmacology and therapeutics, 100(5), 419-422. doi:10.1002/cpt.439
 
Davis, T. P. (2015). Targeting transporters: Promoting blood-brain barrier repair in response to oxidative stress injury. Brain Research, 1623, 39-52. doi:10.1016/j.brainres.2015.03.018
 
Ronaldson, P., Lochhead, J. J., McCaffrey, G., Sanchez-Covarrubias, L., Finch, J. D., Demarco, K. M., Quigley, C. E., Davis, T. P., & Ronaldson, P. T. (2012). Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain. American journal of physiology. Heart and circulatory physiology, 302(3).
 
Presentations
 
Ronaldson, P. T. (2017, February). Targeting Blood-Brain Barrier Transporters: Implications for Treatment of Diseases with a Hypoxia/Reoxygenation Component. Invited Seminar. Amarillo, TX: Texas Tech University Health Sciences Center.
 
Ronaldson, P. T. (2017, November). Targeting Blood-Brain Barrier Transporters for CNS Drug Delivery. 12th International Conference on Cerebral Vascular Biology. Melbourne, Australia: International Brain Barriers Society.
 
Ronaldson, P. T. (2016, February). Blood-Brain Barrier Drug Transporters in Cerebral Hypoxia: Implications for Ischemic Stroke Treatment. 2016 International Stroke Conference. Los Angeles, CA: American Heart Association.
 
Sponsored Research Through MSRP: 
Billy Evans, (MSRP 2021): "Effects of Atorvastatin on Hypothermia-Induced Changes to Blood-Brain Barrier Functional Integrity."
 
NIH High School Student Research Program: 
Alyssa Antone, Tohono O'odham High School, 2013
Vivian Figueroa, San Miguel High School, 2021
 
Wednesday, March 7, 2018