Regents Professor
Clinical Professor, Biomedical Engineering
Associate Department Head, Clinical / Industrial Affairs
Professor, Materials Science and Engineering
Professor, Medical Imaging
Professor, BIO5 Institute
Clinical Professor, Biomedical Engineering
Associate Department Head, Clinical / Industrial Affairs
Professor, Materials Science and Engineering
Professor, Medical Imaging
Professor, BIO5 Institute
Regents Professor, Chemical and Environmental Engineering
Professor, Surgery
Education:
- University of Cincinnati College of Medicine, 1981(M.D.)
Honors and Awards:
- Chairman, Science Advisory Board for MicroMed Cardiovascular, 2009
Major Areas of Research Interest:
Innovation Science and Invention;Inventive Knowledge Flow;Intravascular Stents;Intravascular Biodegradable Polymer-based Support and Drug Delivery Systems - Polymeric Endoluminal Paving and Sealing;Cell Biology of Restenosis and Vascular Wound Healing;Intravascular Ultrasound Imaging;Smooth muscle cell integrin - matrix interactions; Integrin Biology – role in cell locomotion;Estrogen and Smooth Muscle Cell Migration and Integrin Expression;Myocardial angiogenesis and alternative revascularization means;Mechanical Circulatory Support – TAH/VAD, Mechanical & Biomaterial Issues;Oral-Body Inflammatory Connection – Periodontal Disease and CAD;Flexible/Stretchable Bioelectronics;Microfluidics and Medical Diagnostics;Microchip Medical Diagnostics;Grape Polyphenolics, Inflammation and CAD;Bioglass Biomaterials;Nanotextured Biomaterials/Surface Endothelialization;Mathematical Modeling/Enhanced CFD of Mechanical Circulatory Support; Systems for Improved Thromboresistance;Biodegradable/Transient electronic systems;Wearable Health Systems;Microfluidic Point-of-Care Systems;Big Data Tools for Health Care;Microbiome and Its Impact on CV Diz and Chronic Disease;Piezoelectric Biomaterials;Soft Robotics;Virtual Realty Systems;
Selected Publications:
Consolo, F., Dimasi, A., Rasponi, M., Valerio, L., Pappalardo, F., Bluestein, D., Slepian, M. J., Fiore, G. B., & Redaelli, A. (2016). Microfluidic approaches for the assessment of blood cell trauma: a focus on thrombotic risk in mechanical circulatory support devices. The International journal of artificial organs, 0.
Copeland, J., Copeland, H., Nolan, P., Gustafson, M., Slepian, M., & Smith, R. (2016). Results with an anticoagulation protocol in 99 SynCardia total artificial heart recipients. ASAIO journal (American Society for Artificial Internal Organs : 1992), 59(3), 216-20.
Crosby, J. R., DeCook, K. J., Tran, P. L., Smith, R. G., Larson, D. F., Khalpey, Z. I., Burkhoff, D., & Slepian, M. J. (2016). Physiological characterization of the SynCardia total artificial heart in a mock circulation system. ASAIO journal (American Society for Artificial Internal Organs : 1992), 61(3), 274-81.
El Banayosy, A., Kizner, L., Arusoglu, L., Morshuis, M., Brehm, C., Koerfer, R., Schuermann, C., Smith, R. G., Copeland, J. G., & Slepian, M. J. (2016). Home discharge and out-of-hospital follow-up of total artificial heart patients supported by a portable driver system. ASAIO journal (American Society for Artificial Internal Organs : 1992), 60(2), 148-53.
Herskowitz, A., Tamura, F., Ueda, K., Neumann, D. A., Slepian, M., Rose, N. R., Beschorner, W. E., Baumgartner, W. A., Reitz, B. R., & Sell, K. W. (2016). Induction of donor major histocompatibility complex antigens in coronary arterial vessels: mechanism of arterial vasculitis in rat allografts treated with cyclosporine. The Journal of heart transplantation, 8(1), 11-9.
Khalpey, Z., Bin Riaz, I., Marsh, K. M., Ansari, M. Z., Bilal, J., Cooper, A., Paidy, S., Schmitto, J. D., Smith, R., Friedman, M., Slepian, M. J., & Poston, R. (2016). Robotic Left Ventricular Assist Device Implantation Using Left Thoracotomy Approach in Patients with Previous Sternotomies. ASAIO journal (American Society for Artificial Internal Organs : 1992), 61(6), e44-6.
Sponsored Research Through MSRP:
Theodore Lin, (MSRP 2016): "Porogenicity of Platelets"
Catherine Jerman, (MSRP 2017): "Acoustic-Activation of Platelets: A Newly Recognized Mechanism Underlying Thromboembolic Events Associated with Snoring and Obstructive Sleep Apnea -- An Examination of Mechanisms and Modulation"
Shirzad Shir, (MSRP 2019): "Oxidized Low Density Lipoprotein Amplifies Shear-Mediated Platelet Activation"
Haley Owen, (MSRP 2020): "The Differential Response of Aged Platelets versus Younger Platelets to Physical and Biochemical Stimuli"
Ashley Vincent, (MSRP 2020): "“Digital Reflexes” Quantitation and Signatures of Superficial Reflexes via Stretchable Electronic Wearable Sensors"
Katherine Riordan, (MSRP 2022): "Platelet Stiffness: A Newly-Recognized Modifiable Variable in Heart Failure-Associated Thrombosis: Impact of Hyponatremia"
Advanced Research Distinction Track (RDT):
Catherine Jerman, (RDT Class of 2020): "Acoustic-Activation of Platelets: A Newly Recognized Mechanism Underlying Thromboembolic Events Associated with Snoring and Obstructive Sleep Apnea -- An Examination of Mechanisms and Modulation"
Haley Furman, (RDT Class of 2023): "Smartphone-Based Motion Capture: Defining the Operating Envelope for Clinical Application"
Ashley Vincent, (RDT Class of 2023): "Advancing the Telemedicine Physical Exam"
NIH Undergraduate Diversity Program:
Katrina DeCook, 2012, "Effect of ECM Proteins on HUVEC Migration"
Corey Edwards, 2013, "Biomedical Engineering: Summer Clinical Immersion 2013"
Samuel Dunn, 2014, "Red Blood Cell Hemolysis: Is it a Risk or a Marker Factor in VAD Thrombosis?"
Emily Ramirez, 2014, 2015: "The Effects of BMP-13 on the Osteogenic Activity of hASCs", "Investigating New CPR Methods and Repairing Heart Tissue with Cell-Based Therapy"
Marianna Jubis, 2019, "Platelets and Heart Disease"
Marco Moreno, 2020, "Acoustic Platelet Activation: How it Relates to Thrombosis and Obstructive Sleep Apnea "
Tawanda Zvavamwe, 2021, "Prothrombin Acetylation"
NIH High School Student Research Program:
Gaddy Lopez, Cholla High School, 2016
Paloma Orozco, Rio Rico High School (Rio Rio, AZ), 2016
Kyle Wilson, Greyhills Academy High School (Tuba City, AZ), 2017
Shanielle Dodson, Greyhills Academy High School (Tuba City, AZ), 2018
Remun Madlol, Catalina High Magnet School, 2018, 2019
Terilyn Robbins, Greyhills Academy High School (Tuba City, AZ), 2019
David Canez, Pueblo High School, 2020
Syahmi Mohd Rizal, Flowing Wells High School, 2020
Sophia Buchanan, BASIS Tucson North, 2021
Sophia Michel, Douglas High School (Douglas, AZ), 2021
Monday, July 30, 2018