Lalitha Madhavan, MD, PhD

Assistant Professor, Neurology
Assistant Professor, Evelyn F Mcknight Brain Institute
Assistant Professor, Molecular and Cellular Biology
Assistant Professor, BIO5 Institute
Assistant Professor, Medicine
Assistant Professor, Neuroscience - GIDP
Assistant Professor, Physiological Sciences - GIDP

 

Education: 

MD: Baroda Medical College, Vadodara, India
PhD: Neuroscience, Iowa State University, Ames, IA

 

Major Areas of Research Interest: 

Broad Interests: Neuroscience and Stem Cell BiologySpecific Interests: Aging and Neurodegeneration, Role of endogenous neural stem cells in development and disease, Graft-host interactions after neural transplantation, Central nervous system plasticity and regeneration, Disease modeling using patient-specific iPS cells and their derivatives

Selected Publications: 

Corenblum, M. J., Flores, A. J., Badowski, M., Harris, D. T., & Madhavan, L. (2015). Systemic human CD34(+) cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration. Regenerative medicine, 10(5), 563-77.

Madhavan, L. (2015). Redox-based regulation of neural stem cell function and Nrf2. Biochemical Society transactions, 43(4), 627-31.

Madhavan, L., Daley, B. F., Davidson, B. L., Boudreau, R. L., Lipton, J. W., Cole-Strauss, A., Steece-Collier, K., & Collier, T. J. (2015). Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PloS one, 10(9), e0137136.

Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B., Celano, S. L., Green, J. J., Imus, N. M., Marckini, N., Daley, B., Steece-Collier, K., & Collier, T. J. (2015). Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 874-83.

Paumier, K. L., Sortwell, C. E., Madhavan, L., Terpstra, B., Daley, B. F., & Collier, T. J. (2015). Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system. Experimental neurology, 266, 11-21.
 
Gombash, S. E., Lipton, J. W., Collier, T. J., Madhavan, L., Steece-Collier, K., Cole-Strauss, A., Terpstra, B. T., Spieles-Engemann, A. L., Daley, B. F., Wohlgenant, S. L., Thompson, V. B., Manfredsson, F. P., Mandel, R. J., & Sortwell, C. E. (2012). Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular therapy : the journal of the American Society of Gene Therapy, 20(3), 544-54.

 

NIH Undergraduate Diversity Program: 

Samar Iftikhar, 2017, "How do we study Parkinson’s disease?"

NIH High School Student Research Program: 

Justine Davis, Red Mountain High School, 2016

Nhat Nguyen, Catalina Magnet High School, 2017

Tuesday, August 29, 2017