John A. Szivek, PhD

Rubin Professor of Orthopaedic Research, Orthopaedic Surgery
Director, Orthopedic Research Laboratory

Education: 
  • University of Toronto, Department of Metallurgy & Material Sciences, 1979 (Master of Applied Science, Bioengineering)
  • University of Toronto, 1984 (Ph.D., Bioengineering)
  • University of Toronto, College of Dentistry, Biomaterials Department,1985 (Post-Doctoral Fellow)
Honors and Awards: 
  • Ontario Graduate Scholarship, 1980-1984
  • University of Toronto Open Scholarship, 1979-1984
  • Outstanding presentation, The Knee Society, Philadelphia; selected paper for presentation at International Society meeting in Copenhagen, June, 1992
  • Outstanding Publication of the Year, Journal of Investigative Surgery, Vol. 5, pp. 91-108, 1992
  • NIH-NCRR Certificate of Recognition, High School Research Apprentice Program, 1992
  • NIH-NIAID Student Researcher Training Travel Award (granted to student carrying out strain gauge studies in lab), 1993
  • Louis J. Kettel Faculty Mentor Award, Clinical Sciences Mentor, Medical Student Research Program, 1995
  • Alberta Visiting Professor Award, Alberta Heritage Foundation, 1997
  • Department of Surgery, Faculty Mentor Honor Roll, 1998
  • Rubin Endowed Chair in Orthopaedic Research, 2003
  • William and Sylvia Ruben Endowed Chair for Orthopedic Research, 2003
  • National Science Foundation Lousi Stokes Alliance for Minority Participation (LSAMP)
  • WAESO Mentor of the Year, 2003
  • University Animal Care, Investigator of the Year Award, 2005
  • Outstanding Faculty Mentor, U.B.R.P., University of Arizona, 2008 
Major Areas of Research Interest: 

Orthopaedic research in my laboratory is focused on developing cartilage and bone regenerative techniques with tissue engineering approaches using synthetic scaffolds and adult stem cells extracted from fat tissue. The range of research projects related to this work includes biomaterials studies to develop a variety of scaffolds prepared on a 3D printing system from microCT images of bone tissue, biomechanics studies to evaluate strength and stiffness characteristics of implantable scaffolds, computer based finite element modeling of scaffolds and tissues, software development for implantable transmitters, physiological test development to test scaffolds under physiological loading conditions, cell studies involving development of extraction, sorting , conversion and cell alignment techniques.

The overall goal of all these projects is development of clinically viable tissue engineering techniques that include monitoring of healing using sensors and implantable transmitters.

My involvement in the Orthopaedic residency program includes instructing residents in orthopedic biomaterials and biomechanics, providing laboratory support for students and surgical faculty to carry out bench top research projects, participating in radiology teaching conference to provide biomaterials and biomechanics expertise applied to surgical procedures. Student opportunities include learning about implant development and design, biomaterials and biomechanics research in orthopedics as well as tissue engineering strategies to regenerate bone and cartilage.
 

Student Opportunities Through Research: 

Dr. Szivek's involvement includes instructing residents in orthopedic biomaterials and biomechanics, to provide laboratory support for students and surgical faculty to carry out bench top research projects, participate in radiology teaching conference to provide biomaterials and biomechanics expertise applied to surgical procedures. Student opportunities include learning about implant development and design, biomaterials and biomechanics research in orthopedics.

Selected Publications: 

Geffre, CP, PR Finkbone, CL Bliss, DS Margolis, JA Szivek: Load measurement accuracy from sensate scaffolds with and without a cartilage surface. J Investigative Surgery, 23, 156–162, 2010.

Geffre, CP, J Ochoa, JA Szivek, DS Margolis: Evaluation of chitosan-calcium phosphate bone fillers. J Investigative Surgery, 23, 134–141, 2010.

CP Geffre, JA Szivek, JT Ruth, DW DeYoung, B Tellis, DS Margolis: Novel biomimetic polymer scaffold design enhances bone ingrowth. Online Dec 2, DOI: 10.1002/jbm.a.32251 JBMR-A, 2008.

Szivek JA, V Nandakumar, CP Geffre, C Townsend: A handheld computer as part of a portable in vivo knee joint load monitoring system. ASME J of Med Devices, Design Innovation Paper, Vol: 2- 3: 1-10, 2008.

Margolis DS, JA Szivek, LW Lai, YH Lien: Phenotypic characteristics of bone in carbonic anhydrase II deficient mice. Calcified Tissue International, 82:66-76, 2008.

Geffre CP, CL Bliss, JA Szivek, DW DeYoung, JT Ruth, DS Margolis: Sensate Scaffolds Coupled to Telemetry can Monitor In Vivo Loading from within a Joint over Extended Periods of Time. J Biomed Mater Res–B, 84B:263-270, 2008.

Margolis, DS, CP Geffre, JA Szivek, L Lai, YH Lien: CPC coated strain gauges can monitor in vivo bone strain in a mouse. J Invest Med, 56 (1) 327 Suppl., 2008.
Ferng, AS, CW Ferguson, JA Szivek: inducing cartilage regeneration with stem cells for treatment of osteoarthritis patients. FASEB Journal, 22: 819.1, 2008.

Tellis, BC, JA Szivek, CL Bliss, DS Margolis, RK Vaidyanathan, P Calvert: Trabecular scaffolds created using micro ct guided fused deposition modeling. J Materials Science & Engineering–C, Vol 28/1 pp 171-178, 2008.

Geffre, CP, JA Szivek, DS Margolis: Comparison of bone ingrowth into scaffolds with simple and novel biomimetic porous architectures. J Invest Med, 56 (1) 242 Suppl., 2008.

Manson, P, JA Szivek, N Webber: Scanning and characterization of human scaffolds for cartilage tissue engineering. J Invest Med, 56 (1) 327 Suppl., 2008.

Geffre CP, CL Bliss, JA Szivek, DW DeYoung, JT Ruth, DS Margolis: Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time, accepted for publication in J Biomed Mater Res–B, Manuscript ID JBMR-B-06-05-37, 2007.

Bliss CL, JA Szivek, BC Tellis, DS Margolis, AB Schnepp, RT Ruth: Sensate scaffolds can reliably detect joint loading. Journal of Biomedical Materials Research–B, Appl Biomats, 81B, 30-39, 2007.

Tellis BC, JA Szivek, CL Bliss, DS Margolis, RK Vaidyanathan, P Calvert: Trabecular Scaffolds Created Using Micro CT Guided Fused Deposition Modeling, in press, J of Materials Science & Engineering– C, Manuscript ID MSC/01/06/MCP, available online at sciencedirect.com 2007.

Szivek JA, DS Margolis, AB Schnepp, WA Grana, SK Williams: Selective cell proliferation can be controlled with CPC Particle Coatings, J Biomed Mater Res–A, 81A, 939-947, 2007.

Margolis, DS, D Pennington, JA Szivek, WA Grana, L Furenlid, D Wilson, LW Lia, YH Lien: In vivo strain gauge attachment to mouse femora. J Invest Med , 54 (1): S116-S116, 212 Suppl. S Jan 2006.

Szivek JA, CL Bliss, CP Geffre, DS Margolis, DW DeYoung, JT Ruth, AB Schnepp, CB Tellis, RK Vaidyanathan: An instrumented scaffold can monitor loading in the knee joint. J Bio Mat Res-B, 79B, 218-228, 2006.

Margolis DS, D Kim, JA Szivek, LW Lai, YH Lien: Functionally improved bone in Calbindin-D28K knockout mice. Bone 39, 477-484, 2006.
Szivek JA, CL Bliss, CP Geffre, DS Margolis, DW DeYoung, JT Ruth, AB Schnepp, BC Tellis, RK Vaidyanathan: An instrumented scaffold can monitor loading in the knee joint. J Bio Mat Res-B, 79B, 218-228, 2006.

Szivek, JA, CL Bliss, C Geffre, DS Margolis, DW DeYoung, JT Ruth, AB Schnepp, B Tellis, RK Vaidyanathan: Porous polybutylene terephthalate implants allow for bone ingrowth and provide a well-anchored scaffold that can be used to deliver tissue-engineered cartilage. J Invest Med , 54 (1): S116-S116 213 Suppl. S, 2006.

Szivek, JA, RF Roberto, DS Margolis: In Vivo Strain Measurements from Hardware and Lamina during Spine Fusion. J Biomed Mater Res-B 75B:243-250, 2005.

Szivek, JA, D Margolis, BK Garrison, E Nelson, RK Vaidyanathan, DW DeYoung: TGF-ß1-enhanced TCP-coated sensate scaffolds can detect bone bonding. J Biomed Mate Res-B, Vol: 73B-1, 43-53, 2005.

Margolis, DS, YH Lien, L Lai, JA Szivek: Bilateral symmetry of biomechanical properties in mouse femora. Med Engineering & Physics, Vol: 26-4, 349-353, 2004.

Margolis, DS, D Kim, JA Szivek, L Lai, G Kastis, YH Lien: Decreased osteoblast activity in carbonic anhydrase II deficient mice causes osteoporotic bone. J Invest Med, 52 (1): S80-S80, 2004.

Wilson, DL, JA Szivek, PL Anderson, VL Miera, GA Battraw, D DeYoung: A mechanical and histomorphometric analysis of bone bonding by hydroxyapatite-coated strain gages. J of Investigative Surg. 11: 1, 29-48, 1998.

Benjamin, JB, JA Szivek, AS Hammond, Z Kubchandhani, AI Matthews: Contact areas and pressures between native patellae and prosthetic components. J Arthroplasty. 13 (6): 693-698, 1998.

Szivek JA, J Thompson, JB Benjamin: Three synthetic foams used to model a range of properties of human cancellous bone. J Appl Biomats, 6 (2):125-128, 1995.

Szivek JA, RC Kersey, D DeYoung, JT Ruth: Load transfer near hydroxyapatite coated hip implants. J Appl Biomats, 5, 4, 293-306, 1994.

Sponsored Research Through MSRP: 
Michael Dersam (MSRP 1992): "Biomechanics of bone allograft."
 
Robert Kersey (AHA FELLOWSHIP 1992): "Strain redistribution near proximally hydroxyapatite coated hip implants."
 
Joel Thompson (MSRP 1993): "Cancellous screw pullout in osteoporotic and osteoarthritic bone."
 
Deborah Wilson (MSRP 1993): "Model for assessing blood flow vs. strain factors in bone loss in space: Hydroxyapatite strain gauge bonding to rodent femora."
 
David Amstutz (MSRP 1996): "Feedback transmitter for orthopedic knee implants."
 
Tony Matthews (MSRP 1996): "Analysis of contact pressures of the patellofemoral joint to determine the merits of patellar resurfacing versus the native patellae in total knee arthroplasty."
 
Anthony Admire (MSRP 1998): "Material and mechanical aspects of knee implant wear."
 
Harvinder Maan (MSRP 1998): "Development of a knee telemetry data capture and feedback system."
 
Chad Fleming (MSRP 1999): "Precision laser measurement of polyethylene inserts removed from post-arthroplasty knees."
 
Andrew Price (MSRP 1999): "Monitoring spinal fusion in scoliosis patients."
 
Jennifer Slack (MSRP 1999): "Assessing spine fusion using calcium phosphate coated strain gauges."
 
Benjamin Muir (MSRP 2001): "Testing of a synthetic bone graft to measure loading changes during fusion."
 
Murat Dag (MSRP 2002): "Calibration of sensate scaffolds."
 
Jason Davis (MSRP 2004, 2006): "Characterizing native and engineered Hyaline cartilage using OCT."
 
Patrick Finkbone (MSRP 2004): "Failure strength of three suture materials following cyclic abrasion through an eyelet."
 
Chris Geffre (MSRP 2006, 2007): "In vivo load monitoring of the canine stifle during gait" and "Measurement and characterization of bone ingrowth into polymer scaffolds coated in TGF-ß1 and calcium phosphate ceramic particles."
 
Paul Manson (MSRP 2007): "Scanning, production and characterization of human-sized scaffolds for cartilage tissue engineering."
 
David Margolis (MSRP 2007): "In vivo strain gauge attachment to mouse femora using commercially available hydroxyapatite."
 
Jeremy Nielsen (MSRP 2007): "Developing a mouse model of repetitive impact loading induced osteoarthritis."  
 
Michael Montague (MSRP 2008): "Production, Cadaver Implantation and Analysis of Human-sized Scaffolds for Cartilage Tissue Engineering."
 
Jamie Harris (MSRP 2009): "Development of a human-sized biomimetic scaffold to be tested in an ankle fusion model."
 
Nicholas Walter (MSRP 2009): "Evaluation of adipose derived stem cells collected from an animal model with rheumatoid arthritis and utilized for cartilage tissue regeneration." 
 
Javier Rojas (MSRP 2011): "Correlating the Level of Load-Bearing Activity on the Medial Condyle of Canines and Cartilage Growth"
 
James Heap (MSRP 2012): "Co-Culture of Adipose Derived Stem Cells and Chondrocytes with Surface Modifying Proteins on a Bone Scaffold to Simulate a Potential Tissue Allograft."
 
Jamie Flemming (MSRP 2012): "A Comparison of Phenotype, Genotype, Yeild, and Clinical Application of Adipose Derived Stem Cells Isolated from Adipose Tissue on Different Anatomical Sites."
 
Robert Kay (MSRP 2015): "Testing of a 3D Printed Biomimetic Scaffold to Facilitate Long Bone Segment Regeneration"
 
Advanced Research Distinction Track (RDT): 
Patrick Finkbone (Class of 2008): "Comparison of load measurement accuracy from scaffolds with and without cartilage layers."
 
Paul Manson (Class of 2010): "In vivo strain guage attachment to mouse femora."
 
David Margolis (Class of 2010): "In vivo strain guage attachment to mouse femora." 
 
Chris Geffre (Class of 2012): "Real-time strain monitoring in mice during gait." 
 
Mike Montague (Class of 2012): "Design and production of three scaffold models toward the development of a human scaffold to support tissue engineered cartilage."
 
Javier Rojas (Class of 2014): "Correlating the Level of Load-Bearing Activity on the Medial Condyle of Canines and Cartilage Growth."
 
Jamie Fleming (Class of 2015): "A Comparison of Phenotype, Yield, and Clinical Application of Adipose Derived Stem Cells Isolated from Adipose Tissue of Different Anatomical Sites."
NIH High School Student Research Program: 

-Laurel Cox, Tucson High Magnet School, 2003 [awarded 2008 UA President Merril P. Freeman Medal]
-Cassy J. Baha, Alchesay High School (Whiteriver, AZ), 2004
-Phi Tran, University High School, 2008
 

NIH K-12 Science Teacher Program: 

-Joan Binder, Utterback Magnet Middle School, 1994

Friday, January 13, 2017