John Konhilas, BA, MS, PhD

Associate Professor, Department of Physiology

Education: 
Duke University, Durham, North Carolina Cert. 1988-1992 Neuroscience
Duke University, Durham, North Carolina BA 1988-1992 Art History
University of Illinois at Chicago 1992-1994 Biological Sciences
University of Illinois at Chicago MS 1994-1996 Biological Sciences
University of Illinois at Chicago PhD 1996-2001 Physiology/Biophysics
 
Honors and Awards: 
2000            Kiichi Sagawa Young Investigator Award runner up. Cardiovascular Systems Dynamics Society: Baltimore, MD: Sept. 2000.
 
2002            Outstanding Poster Award. Cardiovascular Systems Dynamics Society: Osaka, Japan: 2002.
 
2002-2005  National Research Service Award, Fellowship
 
2003            New Investigator Award. Molecular Mechanisms of Growth, Death and Regeneration in the Myocardium: Basic Biology and Insights into Ischemic Heart Disease and Heart Failure, August, 2003, Salt Lake City, Utah.
 
2007            New Investigator Award. Cardiovascular Repair and Regeneration: Structural and Molecular Approaches in the Cellular Era. AHA, July-August, 2007, Keystone, CO.
 
2015           Special Lecture. Minority Health Disparities. University of Arizona
 
2016           Special Lecture. Minority Health Disparities. University of Arizona
 
2017           Biomedical Engineering Builder’s Day Award for Dedication and Service. University of Arizona
 
2017           American Heart Special Western States Affiliate Research Insights.
 
Selected Publications: 

Konhilas, J.P., Irving, T.C., and de Tombe P.P. Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of inter-filament spacing. 2002. Circulation Research.  90; 59-65.

Journal Cover (Circ Res).

Konhilas, J.P., Irving, T.C., and de Tombe P.P.  Length-dependent activation in three striated muscle types of the rat. 2002. Journal of Physiology (London). 544; 225-236.

Konhilas, J.P., Irving, T.C., Arteaga, G.M., Wolska, B.M., Martin, A.F., Solaro, R.J. and de Tombe, P.P. Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. 2003. Journal of Physiology (London). 547; 951-961.

Behunin SM, Lopez-Pier MA, Birch CL, L.A. M, Danilo C, Khalpey Z, and Konhilas JP. The upstream AMP-activated kinase kinase complex, LKB1/Mo25/STRAD, uniquely impacts sarcomeric contractile function and posttranslational modification. 2015. Biophys J. 108:1484-94.

McKee, L.A., Chen, H., Regan, J.A., Behunin, S.M., Walker, J.W., Walker, J.S., and Konhilas, J.P. Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice. 2013. Archives of Biochemistry and Biophysics. 535; 39-48.

Konhilas, J.P., Watson, P.A., Maass, A.H., Boucek, D.M., Horn, T., Stauffer, B.L., Luckey, S.W., Rosenberg, P., and Leinwand, L.A. Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 2006. Circulation Research.  98; 540-8.

Editorial comment. 2006. Circulation Research. 98; 443-5.

Lipovka, Y., Chen, H., Vagner, J., Price, T.J., Tsao, T., and Konhilas, J.P. Oestrogen receptors interact with the alpha catalytic subunit of AMP-activated protein kinase to regulate its activity. 2015. Biosci Rep.

Pollow, DP Jr, Romero-Aleshire MJ, Sanchez JN, Konhilas JP, Brooks HL. Ang II-induced hypertension in the VCD mouse model of menopause is prevented by estrogen replacement during perimenopause. Am J Physiol Regul Integr Comp Physiol. 2015. In press.

Danilo CA, Constantopoulos E, McKee, L.A., Chen H, Regan J.A., Lipovka Y, Lahtinen S, Stenman LK, Thuy-Vi V. Nguyen TV, Doyle KP, Slepian MJ, Zain I. Khalpey ZI, Konhilas JP. 2017. Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse. Benef Microbes.

Stauffer, B.L., Konhilas, J.P., Head, E., and Leinwand, L.A. Soy diet worsens heart disease in mice. 2006. Journal of Clinical Investigation. 116; 209-
Konhilas, J.P., Chen, H., Luczak, E., McKee, L.A.K., Regan, J., Watson, P.A., Stauffer, B.L., McKinsey, T.A., Horn, T., LaFleur, B., Leinwand, L.A. Diet and sex modify exercise and cardiac adaptation in the mouse. 2015. American Journal of Physiology. 308:H135-45.

Selected for APSselect by the American Physiological Society

Luczak E.D., Barthel, K., Stauffer, B.L., Konhilas, J.P., Cheung, T.H., and Leinwand, L.A. Remodeling the cardiac transcriptional landscape with diet. 2011. Physiol Genomics. 43; 772-780.

Editorial comment. 2006. J Clin Invest. 116; 209-16.

Sponsored Research Through MSRP: 

Eric Hines (MSRP 2017): "The Impact of Post-Exercise Hydration with Deep-ocean Mineral Water on Post-Exercise Rehydration and Lower Body Exercise Performance in Collegiate Athletes"

Wednesday, September 6, 2017