Associate Professor, Medicine
Fax: (520) 626-7071
- Fellowship: Medical Genetics, University of Washington, Seattle, WA
- Residency: Internal Medicine, St. Vincent Hospital, Indianapolis, IN
- Doctorate: University of Illinois
- Medical School: University of Illinois College of Medicine at Urbana-Champaign
- Undergraduate School: Butler University, Indianapolis, IN
I hypothesize that genetic risk factors have been missed because association studies have sought single nucleotide polymorphisms that associate with risk, but have ignored structural variation causing gene copy number changes. One focus of my research is to look for gene copy number variation (CNV) in candidate genes in the vitamin D, polyamine, and selenium pathways, as well as selected other genes linked to colon cancer risk in order to identify genetic risk factors for colorectal neoplasm.
A second research direction addresses appropriate targeting of chemoprevention strategies. I am participating in a project to test the safety of using DFMO and sulindac as a chemopreventive strategy in children with FAP, which we hope to follow with a study of efficacy.
Laukaitis, C. M., Critser, E. S. and Karn, R. C. (1997) Salivary androgen-binding protein (ABP) mediates sexual isolation in Mus musculus. Evolution. 51(16): 2000-2005.
Knight, B., Laukaitis, C. M., Akhtar, N., Hotchin, N. A., Edlund, M. and Horwitz, A. R. (2000) Visualizing cell migration in situ. Current Biology. 10: 576-585. PMID: 10837222
Laukaitis, C. M., Donais, K., Webb, D. J., and Horwitz, A. F. (2001) Differential dynamics of a5 integrin, paxillin, and a-actinin during formation and disassembly of adhesions in migrating cells. Journal of Cell Biology. 153(7):1427-1440. PMID: 11425873
Talley, H. M., Laukaitis, C. M., Karn, R. C. (2001) Female preference for male saliva: Implications for sexual isolation of Mus musculus subspecies. Evolution. 55(3): 631-634. PMID: 11327170
Karn, R.C. and Laukaitis, C.M. (2003) Characterization of two forms of mouse salivary androgen-binding protein (ABP): Implications for evolutionary relationships and ligand-binding function. Biochemistry. 42(23):7162-7170. PMID: 12795612
Laukaitis, C.M., Dlouhy, S.R., and Karn, R.C. (2003) The mouse salivary androgen-binding protein (ABP) gene cluster on chromosome 7: Characterization and evolutionary relationships. Mammalian Genome. 14:679-691. PMID: 14694904
Emes, R.D., Riley, M.C., Laukaitis, C.M., Goodstadt, L., Karn, R.C., and Ponting, C.P. (2004) Rapid duplication and sequence diversification within the rodent androgen-binding protein (ABP) gene cluster. Genome Research. 14(8):1516-1529. PMID: 15256509
Laukaitis, C.M. and Karn, R.C. (2005) Evolution of the secretoglobins: A genomic and proteomic view. Biological Journal of the Linnean Society. 84:493-501.
Laukaitis, C.M., Dlouhy, S.R., Emes, R.D., Ponting, C.P., and Karn, R.C. (2005) Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculus. BMC Evolutionary Biology. 5:40. PMID: 16018816
Laukaitis, C.M., Heger, A., Blakley, T.D., Munclinger, P., Ponting, C.P., and Karn, R.C. (2008) Rapid bursts of Abp gene duplication occurred independently in diverse mammals. BMC Evolutionary Biology. 8:46. PMID: 18269759
Karn, R.C. and Laukaitis, C.M. (2009) Gene duplication and evolution in a volatile region of the mouse (Mus musculus) genome. Genome Biology and Evolution. 2009:494-503. PMID: 20333217
Karn, R.C., Young, J.M. and Laukaitis, C.M. (2010) A candidate subspecies discrimination system involving a vomeronasal receptor gene with different alleles fixed in M. m. domesticus and M. m. musculus. PLoS One. 5(9): e12638. PMID: 20844586
-Joseph Nantz, Deer Valley High School, 2011