Victor J. Hruby, PhD

Regents Professor Emeritus of Chemistry
Professor Emeritus of Biochemistry and Molecular Biophysics
Professor Emeritus, Arizona Research Laboratories
Professor Emeritus of Neuroscience

Old Chemistry 213-215
P.O. Box 210041
Tucson, AZ 85721-0041

Phone: 
(520) 621-6332
Email Address: 
hruby@u.arizona.edu
Education: 
  • B.S. 1960, University of North Dakota
  • M.S. 1962, University of North Dakota
  • Ph.D. 1965, Cornell University
Honors & Awards: 

1959-1960        Abbott Award; Coon Award; Magna cum laude; University of North Dakota

1961                  NSF Summer Fellow; University of North Dakota

1962                  Sigma Xi; University of North Dakota

1965                  NSF Cooperative Fellow; Cornell University

1972                  American Association Advancement of Science - Fellow

1974                  American Institute of Chemists - Fellow

1975-1976        U.S. Public Health Service Senior Research Fellowship; NIH

1978-1979        Rector's Lectureship; Free University of Brussels

1979                  Fulbright-Hays Fellow

1979                  Pfizer Lecturer, Clinical Research Institute of Montreal

1979                  University Lecturer; University of Baghdad

1981                  New York Academy of Science – Fellow

1981-1982        UNESCO Lecturer; Bangalore, India

1983                  Welsh Lectureship

1984                  Karger Lecturer; University of Oklahoma

1984                  Distinguished Alumni Lecturer; University of North Dakota

1984-1985        Guggenheim Fellowship

1985                  University Lecturer; University of Texas

1986                  American Diabetes Association Research Award

1986                  DuPoint Distinguished Lecturer; University of Indiana

1987                  Javits Neuroscience Award

1988-1996        MERIT Award – NIH

1988                  Merritt-Putnam Lecturship

1989                  Doctor Honorus Causa; Free University of Brussels

1989                  Regents Professor; University of Arizona

1989                  Selectide Corporation- Founder

1991                  University Distinguished Lecturer; Creighton University

1993                  Pierce (ne Merrifield) Award (APS)

1996                  Bloomquist Lecturer, Cornell University

1999-2000        Humboldt Senior Scientist Award - Fellow

2000                  Sieman’s Lecturer, Germany

2001                  Tetrahedron - Guest Editor (with Vadim Soloshonok). Asymmetric Synthesis of Novel Sterically Constrained Amino Acids

2002                  Ralph T. Hirschmann Award (ACS)

2002                  Cathay Award (China)

2003                  Karcher Lecturer; Univeristy of Oklahoma

2003                  Abbott Lecturer; University of North Dakota

2003                  Nolan and Gloria Sommer Award

2005                  Arizona Art, Science & Technology Academy

2006                  Eminent Scholar Lecture; University of Arizona

2006                  Distinguished Career Teaching Award; University of Arizona

2006                  Anniversary Medal; Polish Academy of Sciences

2007                  Goodman Lecturer; University of California San Diego

2009                  Arizona Technology Innovator of the Year; University of Arizona

2009                  Arthur C. Cope Scholar Award (ACS)

2010                  Boehringer Ingelheim Lecturer; University of Montreal

2011                  Murray Goodman Scientific Excellence  Mentorship Award (APS)

Major Areas of Research Interest: 

Peptide hormones and Neurotransmitters, Chemistry, Biophysics, Pharmacology, Physiology & Medical, Pain, Tolerance, Addiction, Obesity, Anorexia, Sexual Function, Pigmentation, Inflammation

Selected Publications: 

I.D. Alves, Z. Salamon, E. Varga, H.I. Yamamura, G. Tollin, and V.J. Hruby. Direct Observation of G-Protein Binding to the Human δ-Opioid Receptor Using Plasmon-Waveguide Resonance Spectroscopy. J. Biol. Chem., 278, 48890-48897 (2003).

 

M. Cai, M. Stankova, S. J.K. Pond, A.V. Mayorov, J.W. Perry, H.I. Yamamura, D. Trivedi, and V.J. Hruby. Real Time Differentiation of G-Protein Coupled Receptor (GPCR) Agonist and Antagonist by Two Photon Fluorescence Laser Microscopy. J. Am. Chem. Soc., 126, 7160-7161 (2004).

 

M. Cai, A.V. Mayorov, C. Cabello, M. Stankova, D. Trivedi, and V.J. Hruby. Novel 3D Pharmacophore of α-MSH/γ-MSH Hybrids Leads to Selective Human MC1R and MC3R Analogues. J. Med. Chem., 48, 1839-1848 (2005).

 

J.P. Cain, A.V. Mayorov, M. Cai, H. Wang, B. Tan, K. Chandler, Y.S. Lee, R.R. Petrov, D. Trivedi, and V.J. Hruby. Design, Synthesis, and Biological Evaluation of a New Class of Small Molecule Peptide Mimetics Targeting the Melanocortin Receptors.

Bioorg. Med. Chem. Letts., 16, 5462-5467 (2006). PMC1810397

 

V.J. Hruby, M. Cai, J.P. Cain, A.V. Mayorov, M.M. Dedek, and D. Trivedi. Design, Synthesis and Biological Evaluation of Ligands Selective for the Melanocortin-3 Receptor. Current Topics Med. Chem., 7, 1085-1097 (2007). PMC2274922

 

A.V. Mayorov, M. Cai, E.S. Palmer, M.M. Dedek, J.P. Cain, A.R. Van Scoy, B. Tan, J. Vagner, D. Trivedi, and V.J. Hruby. Structure-Activity Relationships of Cyclic Lactam Analogues of α-Melanocyte-Stimulating Hormone (α-MSH) Targeting the Human Melanocortin-3 Receptor. J. Med. Chem., 51, 187-195 (2008). PMC2587288

 

Y.S. Lee, R.S. Agnes, J.P. Cain, V. Kulkarni, M. Cai, C. Salibay, K. Ciano, R. Petrov, A. Mayorov, J. Vagner, D. Trivedi, P. Davis, S-W. Ma, J. Lai, F. Porreca, R. Vardanyan, and V.J. Hruby. Opioid and Melanocortin Receptors: Do They Have Overlapping Pharmacophores? Peptide Science, 90, 433-438 (2007). PMC2693099

 

L. Doedens, F. Opperer, M. Cai, J.G. Beck, M. Dedek, E. Palmer, V.J. Hruby, and H. Kessler Multiple N-Methylationof MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies J. Amer. Chem. Soc., 132, 8115-8128 (2010). NIHMSID 208710.

 

D. Torino, A. Mollica, F. Pinnen, F. Feliciani, G. Lucente, G. Fabrizi, G. Portalone, P. Davis, J. Lai, S-W. Ma, F. Porreca, and V.J. Hruby Synthesis and Evaluation of New Endomorphin-2 Analogues Containing (Z)-Œ±,Œ≤-Didehydrophenylalanine (ŒîZPhe) Residues. J. Med. Chem. 53 (11), 4550–4554 (2010).

 

J.S. Josan, H.L. Handl, R Sankanaryanan, L. Xu, R.M. Lynch, J. Vagner, E.A. Mash, V.J. Hruby and R.J. Gillies. Cell Specific Targeting by Heterovalent Ligands. Bioconjugate Chemistry, 22, 1270-1278 (2011)

Student Opportunities Through Research: 
  1. Studies on the design, synthesis and pharmacological evaluation of novel, multivalent ligands for the treatment of prolonged and neuropathic pain without toxicities or the developing of tolerance.
  2. Studies of the synthesis of multivalent ligands with reporter groups and/or drugs for the detection and/or treatment of cancer
  3. Development of melanotropin hormone and neurotransmitter analogues with biological activity profiles for the treatment of feeding disorders, pigmentary disorders, sexual disorders, pain, and immune or inflammatory responses
Sponsored Research Through MSRP: 

Kimberly Hill (MSRP 2012): " Elucidation of Dynorphin a Action at Bradykinin Receptors in CNS and Drug Design for Antagonists at Said Receptors." 

NIH High School Student Research Program: 

 -Joshua Carlin, Basis North High School, 2015

Last Updated: 
December 15, 2015